Dysconnectivity within the default mode in first-episode schizophrenia: a stochastic dynamic causal modeling study with functional magnetic resonance imaging.
Dysconnectivity within the default mode in first-episode schizophrenia: a stochastic dynamic causal modeling study with functional magnetic resonance imaging.
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DOI：
10.1093/schbul/sbu080
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发表时间：
2015-01
影响因子：
6.6
通讯作者：
Friston KJ
中科院分区：
文献类型：
--
作者：
Bastos-Leite AJ;Ridgway GR;Silveira C;Norton A;Reis S;Friston KJ
我们首次报道了精神分裂症默认模式网络(DMN)内有效连通性的随机动态因果模型(SDCM)研究。对33例(女性9例，平均年龄25.0岁，SD=5)首发精神病和精神分裂症诊断的患者进行了研究。健康对照组15例(女性4例，平均年龄24.6岁，SD=4)作为对照。所有受试者均接受静息状态功能磁共振成像(FMRI)检查，中间穿插两个连续的图像观看周期。使用16名独立的健康志愿者的数据(使用相同的fMRI方案)，对DMN的前额叶(AF)、后扣带核(PC)以及左右顶叶节点进行了无偏定位。我们使用sDCM来估计DMN节点之间和节点内的直接连接，随后将其与受试者之间的t测试进行比较。患者组PC结对房颤结节的兴奋作用和对房颤结节自连接的抑制作用(平均值分别为0.013和−0.048 Hz，SD=0.09和0.05)明显弱于健康对照组(平均值分别为0.084和−0.088 Hz，SD=0.15和0.77；P<；0.05)。总之，sDCM显示首发精神分裂症患者与DMN房颤节点的有效连接减少--反映了前额叶传入的突触后效率降低。
We report the first stochastic dynamic causal modeling (sDCM) study of effective connectivity within the default mode network (DMN) in schizophrenia. Thirty-three patients (9 women, mean age = 25.0 years, SD = 5) with a first episode of psychosis and diagnosis of schizophrenia—according to the Diagnostic and Statistic Manual of Mental Disorders, 4th edition, revised criteria—were studied. Fifteen healthy control subjects (4 women, mean age = 24.6 years, SD = 4) were included for comparison. All subjects underwent resting state functional magnetic resonance imaging (fMRI) interspersed with 2 periods of continuous picture viewing. The anterior frontal (AF), posterior cingulate (PC), and the left and right parietal nodes of the DMN were localized in an unbiased fashion using data from 16 independent healthy volunteers (using an identical fMRI protocol). We used sDCM to estimate directed connections between and within nodes of the DMN, which were subsequently compared with t tests at the between subject level. The excitatory effect of the PC node on the AF node and the inhibitory self-connection of the AF node were significantly weaker in patients (mean values = 0.013 and −0.048 Hz, SD = 0.09 and 0.05, respectively) relative to healthy subjects (mean values = 0.084 and −0.088 Hz, SD = 0.15 and 0.77, respectively; P < .05). In summary, sDCM revealed reduced effective connectivity to the AF node of the DMN—reflecting a reduced postsynaptic efficacy of prefrontal afferents—in patients with first-episode schizophrenia.
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影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
影响因子：
6.7
作者：
Friston, KJ
通讯作者：
Friston, KJ
影响因子：
3.1
作者：
Adams, Rick A.;Shipp, Stewart;Friston, Karl J.
通讯作者：
Friston, Karl J.
影响因子：
5.7
作者：
Jafri, Madiha J.;Pearlson, Godfrey D.;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
影响因子：
17.7
作者：
Gardner, David M.;Murphy, Andrea L.;Baldessarini, Ross J.
通讯作者：
Baldessarini, Ross J.