Disrupted Brain Network in Children with Autism Spectrum Disorder.
Disrupted Brain Network in Children with Autism Spectrum Disorder.
复制标题
自闭症谱系障碍儿童的大脑网络遭到破坏
DOI：
10.1038/s41598-017-16440-z
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发表时间：
2017-11-24
影响因子：
4.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Zeng K;Kang J;Ouyang G;Li J;Han J;Wang Y;Sokhadze EM;Casanova MF;Li X
自闭症谱系障碍（ASD）患者的脑连接改变已被广泛报道，但其对脑网络拓扑结构的影响尚不清楚。本研究利用静息态脑电图研究ASD儿童的脑网络是否以及如何异常组织。时间同步分析首先应用于捕获异常的大脑连接。然后采用常用的加权图、二叉图和最小生成树三种图分析方法对脑网络拓扑结构进行了表征。与典型发育儿童（TD）相比，ASD组的全脑连接性在θ和α波段显著降低。加权图发现路径长度显著减少，并且ASD中α带的聚类系数略微显著减少，表明随机网络失去了小世界架构。这种不正常的网络拓扑结构在二进制图中也得到了证明。在MST分析中，ASD儿童表现出显着较低的叶分数，在α带的树层次结构的下降趋势，这表明在ASD中向线状分散组织的转变。改变的大脑网络可以提供对ASD潜在病理学的洞察，并可能作为有助于ASD诊断的生物标志物。
Alterations in brain connectivity have been extensively reported in autism spectrum disorder (ASD), while their effects on the topology of brain network are still unclear. This study investigated whether and how the brain networks in children with ASD were abnormally organized with resting state EEG. Temporal synchronization analysis was first applied to capture the aberrant brain connectivity. Then brain network topology was characterized by three graph analysis methods including the commonly-used weighted and binary graph, as well as minimum spanning tree (MST). Whole brain connectivity in ASD group was found to be significantly reduced in theta and alpha band compared to typically development children (TD). Weighted graph found significantly decreased path length together with marginally significantly decreased clustering coefficient in ASD in alpha band, indicating a loss of small-world architecture to a random network. Such abnormal network topology was also demonstrated in the binary graph. In MST analysis, children with ASD showed a significant lower leaf fractions with a decrease trend of tree hierarchy in the alpha band, suggesting a shift towards line-like decentralized organization in ASD. The altered brain network may offer an insight into the underlying pathology of ASD and possibly serve as a biomarker that may aid in diagnosis of ASD.
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DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bullmore, Edward T.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.
影响因子：
4.7
作者：
Catarino, Ana;Churches, Owen;Ring, Howard
通讯作者：
Ring, Howard
影响因子：
9.3
作者：
Duffy FH;Als H
通讯作者：
Als H
DOI：
10.1073/pnas.1214533110
发表时间：
2013-02-19
影响因子：
11.1
作者：
Khan, Sheraz;Gramfort, Alexandre;Kenet, Tal
通讯作者：
Kenet, Tal
影响因子：
4.8
作者：
Boersma, Maria;Smit, Dirk J. A.;Stam, Cornelis J.
通讯作者：
Stam, Cornelis J.