The SirT3 divining rod points to oxidative stress.

The SirT3 divining rod points to oxidative stress.
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DOI:
10.1016/j.molcel.2011.05.008
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发表时间:
2011-06-10
期刊:
影响因子:
16
通讯作者:
Guarente L
Guarente L
中科院分区:
生物学1区
文献类型:
--
作者:
Bell EL;Guarente L

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Sirtuins 是 NAD 依赖性脱乙酰酶,可对抗衰老和衰老疾病。 Sirtuin 的研究重点是 SirT1,它可以使细胞核中的转录因子和辅因子去乙酰化。最近的研究结果强调 SirT3 是一种调节代谢和氧化应激的线粒体去乙酰化酶。本综述重点关注将 SirT3 与线粒体活性氧管理联系起来的新数据,这可能对衰老和晚发疾病产生深远影响
Sirtuins are NAD-dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases
SIRT3在饮食限制期间促进尿素周期和脂肪酸氧化。
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