Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats.
Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats.
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DOI：
10.1016/j.bioactmat.2021.03.034
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发表时间：
2021-11
影响因子：
18.9
通讯作者：
Liu B
中科院分区：
文献类型：
--
作者：
Liu C;Fan L;Tian Z;Wen H;Zhou L;Guan P;Luo Y;Chan C;Tan G;Ning C;Rong L;Liu B
导电支架已被证明对周围神经损伤（PNI）患者具有治疗作用。然而，传统的导电导管由刚性结构制成，由于其与神经组织的机械不匹配和可塑性差，对于受损的糖尿病患者的应用受到限制。我们建议开发与本研究中的手术敷料相同的生物相容性导电水凝胶（ECH）。基于优异的粘合和自愈特性，薄膜状敷料可以轻松附着在受伤的神经纤维上，自动扭曲管状结构，无需任何侵入性技术。 ECH 提供与生电神经组织紧密且稳定的电桥耦合。体外实验表明ECH促进雪旺细胞的迁移和粘附。此外，ECH 通过 MEK/ERK 途径在体外和体内促进轴突再生和髓鞘再生，从而防止肌肉去神经萎缩，同时保持功能恢复。这项研究的结果可能有助于开发利用导电水凝胶治疗糖尿病患者 PNI 的非侵入性治疗技术。传统的导电导管由刚性结构制成，对于糖尿病患者的应用有限。自卷曲导电水凝胶具有多孔、高导电性和粘合特性，与手术敷料相同。导电水凝胶通过 MEK/ERK 途径促进轴突再生和髓鞘再生。 ECH 敷料可防止糖尿病大鼠的肌肉失神经萎缩并保持功能恢复。
Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries (PNIs). However, conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity. We propose the development of biocompatible electroconductive hydrogels (ECHs) that are identical to a surgical dressing in this study. Based on excellent adhesive and self-healing properties, the thin film-like dressing can be easily attached to the injured nerve fibers, automatically warps a tubular structure without requiring any invasive techniques. The ECH offers an intimate and stable electrical bridge coupling with the electrogenic nerve tissues. The in vitro experiments indicated that the ECH promoted the migration and adhesion of the Schwann cells. Furthermore, the ECH facilitated axonal regeneration and remyelination in vitro and in vivo through the MEK/ERK pathway, thus preventing muscle denervation atrophy while retaining functional recovery. The results of this study are likely to facilitate the development of non-invasive treatment techniques for PNIs in diabetic patients utilizing electroconductive hydrogels. Conventional conductive conduits are made of rigid structures and have limited applications for diabetic patients. Self-curling electroconductive hydrogel with porous, highly conductive, and adhesive properties were identical to a surgical dressing. Electroconductive hydrogel facilitates axonal regeneration and remyelination via MEK/ERK pathway. ECH dressing prevent muscle denervation atrophy and retain functional recovery in diabetic rats.
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