Fusobacterium nucleatum and colorectal cancer: A review.
Fusobacterium nucleatum and colorectal cancer: A review.
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具核梭杆菌与结直肠癌:综述
DOI:
10.4251/wjgo.v10.i3.71
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发表时间:
2018-03-15
影响因子:
3
通讯作者:
Liu HL
中科院分区:
文献类型:
--
作者:
Shang FM;Liu HL
Fusobacterium nucleatum (F. nucleatum) is a Gram-negative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis. Recently, several studies have reported that the level of F. nucleatum is significantly elevated in human colorectal adenomas and carcinomas compared to that in adjacent normal tissue. Several researchers have also demonstrated that F. nucleatum is obviously associated with colorectal cancer and promotes the development of colorectal neoplasms. In this review, we have summarized the recent reports on F. nucleatum and its role in colorectal cancer and have highlighted the methods of detecting F. nucleatum in colorectal cancer, the underlying mechanisms of pathogenesis, immunity status, and colorectal cancer prevention strategies that target F. nucleatum.
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9
作者:
Göbel C;Breitenbuecher F;Kalkavan H;Hähnel PS;Kasper S;Hoffarth S;Merches K;Schild H;Lang KS;Schuler M
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11.8
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Wynne, B
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7
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Holt, Robert A.