In Vivo Imaging for the Visualization of Extracellular Vesicle-Based Tumor Therapy.
In Vivo Imaging for the Visualization of Extracellular Vesicle-Based Tumor Therapy.
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用于细胞外囊泡肿瘤治疗可视化的体内成像
DOI：
10.1002/open.202200124
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发表时间：
2022-09
期刊：
影响因子：
2.3
通讯作者：
Xie, Hai-Yan
中科院分区：
文献类型：
--
作者：
Jiang, Anqi;Nie, Weidong;Xie, Hai-Yan
Extracellular vesicles (EVs) exhibiting versatile biological functions provide promising prospects as natural therapeutic agents and drug delivery vehicles. For future clinical translation, revealing the fate of EVs in vivo, especially their accumulation at lesion sites, is very important. The continuous development of in vivo imaging technology has made it possible to track the real‐time distribution of EVs. This article reviews the applications of mammal‐, plant‐, and bacteria‐derived EVs in tumor therapy, the labeling methods of EVs for in vivo imaging, the advantages and disadvantages of different imaging techniques, and possible improvements for future work. Revealing the fate of extracellular vesicles (EVs) in vivo, especially their accumulation at lesion sites, contributes to selecting suitable EVs derivation and administration protocols so as to improve their treatment. We summarize the progress of related labeling approaches, imaging techniques, and the possible improvements in the future.
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影响因子：
16
作者：
Imai T;Takahashi Y;Nishikawa M;Kato K;Morishita M;Yamashita T;Matsumoto A;Charoenviriyakul C;Takakura Y
通讯作者：
Takakura Y
影响因子：
8
作者：
Busato A;Bonafede R;Bontempi P;Scambi I;Schiaffino L;Benati D;Malatesta M;Sbarbati A;Marzola P;Mariotti R
通讯作者：
Mariotti R
DOI：
10.1007/s00018-014-1764-3
发表时间：
2015-02
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Brinton LT;Sloane HS;Kester M;Kelly KA
通讯作者：
Kelly KA
影响因子：
17.1
作者：
Bose RJC;Uday Kumar S;Zeng Y;Afjei R;Robinson E;Lau K;Bermudez A;Habte F;Pitteri SJ;Sinclair R;Willmann JK;Massoud TF;Gambhir SS;Paulmurugan R
通讯作者：
Paulmurugan R
影响因子：
4.6
作者：
Garaeva L;Kamyshinsky R;Kil Y;Varfolomeeva E;Verlov N;Komarova E;Garmay Y;Landa S;Burdakov V;Myasnikov A;Vinnikov IA;Margulis B;Guzhova I;Kagansky A;Konevega AL;Shtam T
通讯作者：
Shtam T