Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.
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DOI：
10.1038/nn.2508
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发表时间：
2010-04
影响因子：
25
通讯作者：
Sur, Mriganka
中科院分区：
文献类型：
--
作者：
McCurry, Cortina L.;Shepherd, Jason D.;Tropea, Daniela;Wang, Kuan H.;Bear, Mark F.;Sur, Mriganka
无数的机制被认为可以解释视觉皮层可塑性的丰富性。我们报告说，视觉皮层缺乏弧是不受影响的剥夺或经验。使用内在信号成像和慢性视觉诱发电位记录，我们发现Arc−/−小鼠在短暂的单眼剥夺后不会表现出剥夺眼反应的抑制或眼优势的转变。延长剥夺也未能引起眼优势或睁眼增强的转变。此外，Arc−/−小鼠缺乏刺激选择性反应增强。虽然Arc−/−小鼠表现出正常的视力，但基线眼优势是异常的，与暗饲养后观察到的相似。这些数据表明，Arc是需要的经验依赖的过程，通常建立和修改突触连接在视觉皮层。
A myriad of mechanisms are suggested to account for the full richness of visual cortical plasticity. We report that visual cortex lacking Arc is impervious to the effects of deprivation or experience. Using intrinsic signal imaging and chronic visually evoked potential recordings, we find that Arc−/− mice do not exhibit depression of deprived eye responses or a shift in ocular dominance after brief monocular deprivation. Extended deprivation also fails to elicit a shift in ocular dominance or open eye potentiation. Moreover, Arc−/− mice lack stimulus–selective response potentiation. Although Arc−/− mice exhibit normal visual acuity, baseline ocular dominance is abnormal and resembles that observed after dark–rearing. These data suggest that Arc is required for the experience–dependent processes that normally establish and modify synaptic connections in visual cortex.
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