INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
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DOI：
10.1007/s10038-008-0317-8
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发表时间：
2008
影响因子：
3.5
通讯作者：
Nakamura, Yusuke
中科院分区：
文献类型：
--
作者：
Hotta, Kikuko;Nakamura, Michihiro;Nakata, Yoshio;Matsuo, Tomoaki;Kamohara, Seika;Kotani, Kazuaki;Komatsu, Ryoya;Itoh, Naoto;Mineo, Ikuo;Wada, Jun;Masuzaki, Hiroaki;Yoneda, Masato;Nakajima, Atsushi;Miyazaki, Shigeru;Tokunaga, Katsuto;Kawamoto, Manabu;Funahashi, Tohru;Hamaguchi, Kazuyuki;Yamada, Kentaro;Hanafusa, Toshiaki;Oikawa, Shinichi;Yoshimatsu, Hironobu;Nakao, Kazuwa;Sakata, Toshiie;Matsuzawa, Yuji;Tanaka, Kiyoji;Kamatani, Naoyuki;Nakamura, Yusuke
胰岛素诱导基因2 （INSIG2）上游区域的单核苷酸多态性（SNP） rs7566605与许多高加索人群的肥胖表型有关。在日本，这种与肥胖表型的关系尚不清楚。为了研究rs7566605与日本肥胖的关系，我们从严重肥胖受试者[n = 908，体重指数(BMI)≥30 kg/m2]和正常体重对照受试者（n = 1495, BMI < 25 kg/m2）中分型rs7566605。病例-对照关联分析显示，rs7566605与日本人肥胖显著相关。小等位基因隐性模式的P值为0.00020，性别和年龄校正后的优势比（OR）为1.61[95%可信区间(CI) = 1.24-2.09]。肥胖相关表型，包括BMI、血糖、血红蛋白A1c、总胆固醇、甘油三酯、高密度脂蛋白（HDL）胆固醇和血压水平，与rs7566605基因型无关。由此，我们发现INSIG2基因上游区域rs7566605与日本人肥胖，即重度肥胖相关。
The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case–control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24–2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
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DOI：
10.1073/pnas.0401715101
发表时间：
2004-05-04
影响因子：
11.1
作者：
Takaishi, K;Duplomb, L;Unger, RH
通讯作者：
Unger, RH
影响因子：
3.5
作者：
Yanagiya, Takahiro;Tanabe, Atsushi;Hotta, Kikuko
通讯作者：
Hotta, Kikuko
影响因子：
3.5
作者：
Liu, Yong-Jun;Liu, Xiao-Gang;Deng, Hong-Wen
通讯作者：
Deng, Hong-Wen
影响因子：
4.9
作者：
Smith, A. J. P.;Cooper, J. A.;Humphries, S. E.
通讯作者：
Humphries, S. E.
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.