High serum hepcidin is associated with the occurrence of anemia in anti-myeloperoxidase antibody-associated vasculitis with normal kidney function: a cross-sectional study
High serum hepcidin is associated with the occurrence of anemia in anti-myeloperoxidase antibody-associated vasculitis with normal kidney function: a cross-sectional study
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高血清铁调素与肾功能正常的抗髓过氧化物酶抗体相关性血管炎贫血的发生有关：一项横断面研究
DOI：
10.1007/s00296-019-04292-x
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发表时间：
2019-03
影响因子：
4
通讯作者：
Yan Tie Kun
中科院分区：
文献类型：
--
作者：
Chen Tong;Xu Peng Cheng;Hu Shui Yi;Gao Shan;Jia Jun Ya;Yan Tie Kun
抗神经元胞浆抗体（ANCA）相关性血管炎（AAV）贫血的病因尚未阐明。在这项横断面研究中，我们试图探讨血清铁调素和髓过氧化物酶（MPO）-ANCA-AAV贫血的关系。分析64例新诊断的无肾功能损害或出血的AAV患者的资料。采用酶联免疫吸附法测定血清铁调素水平。64例患者中有23例贫血。与无贫血患者相比，贫血患者的伯明翰血管炎活动评分较高[10（3，23）vs. 5（3，17），p= 0.020]，血清铁水平较低（5.83 ± 1.63vs9.76 ± 1.54，p < 0.001）和较高水平的铁蛋白[358.00（59.85，1314.10）vs151.05（43.00，645.30），p= 0.006]。与正常对照组相比，所有64例患者的血清铁调素水平均升高，而贫血患者的血清铁调素水平高于无贫血患者（85.30 ± 16.92 ng/mL vs. 53.48 ± 13.32 ng/mL，p< 0.001）。在多变量分析中，血红蛋白水平与血清铁（r= 0.344，p = 0.026）和铁调素（r=-0.353，p = 0.022）水平相关。低血清铁水平与高血清铁调素水平相关（r=-0.472，p = 0.001）。免疫抑制治疗后1个月铁调素迅速下降，血清铁迅速升高，而血红蛋白恢复相对缓慢。本研究表明，在无肾功能障碍或出血的MPO-AAV中，贫血的存在与高水平的铁调素引起的低血清铁和铁利用异常有关。
The etiology of anemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been elucidated. In this cross-sectional study, we tried to investigate the relationship between serum hepcidin and anemia in myeloperoxidase (MPO)-ANCA-AAV. Data of 64 newly diagnosed AAV patients who did not have kidney dysfunction or hemorrhage were analyzed. Serum hepcidin was measured with enzyme linked immunosorbent assay. Twenty-three of 64 patients had anemia. Compared with patients without anemia, patients with anemia had higher Birmingham vasculitis activity score [10 (3, 23) vs. 5 (3, 17),p= 0.020], lower levels of serum iron (5.83 ± 1.63 vs. 9.76 ± 1.54,p< 0.001) and higher levels of ferrtin [358.00 (59.85, 1314.10) vs. 151.05 (43.00, 645.30),p= 0.006]. All 64 patients had increased levels of serum hepcidin compared with normal controls, while patients with anemia had higher serum hepcidin than patients without anemia (85.30 ± 16.92 ng/mL vs. 53.48 ± 13.32 ng/mL,p< 0.001). In the multivariable analysis, the level of hemoglobin correlated with the levels of serum iron (r= 0.344,p= 0.026) and hepcidin (r= − 0.353,p= 0.022). Low level of serum iron was related to high level of serum hepcidin (r= − 0.472,p= 0.001). Immunosuppressive treatment induced rapid decrease of hepcidin and increase of serum iron on the 1st month, while the recovery of hemoglobin was relatively slow. This study indicated that in MPO-AAV without kidney dysfunction or hemorrhage, the existence of anemia is associated with high level of hepcidin which induces low serum iron and the abnormality of iron utilization.
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影响因子：
4.2
作者：
Chie Ogawa;K. Tsuchiya;F. Kanda;T. Maeda
通讯作者：
Chie Ogawa;K. Tsuchiya;F. Kanda;T. Maeda
影响因子：
4.6
作者：
Ohlsson S;Wieslander J;Segelmark M
通讯作者：
Segelmark M
影响因子：
4.6
作者：
Rowaiye OO;Kusztal M;Klinger M
通讯作者：
Klinger M
DOI：
10.1007/978-1-4939-7360-6_4
发表时间：
2018
期刊：
--
影响因子：
--
作者：
A. Besarab;S. Hemmerich
通讯作者：
A. Besarab;S. Hemmerich
DOI：
10.1093/oxfordjournals.qjmed.a068882
发表时间：
1994-11
期刊：
QJM : monthly journal of the Association of Physicians
影响因子：
--
作者：
R. Luqmani;P. Bacon;R. Moots;B. A. Janssen;A. Pall;P. Emery;C. Savage;D. Adu
通讯作者：
R. Luqmani;P. Bacon;R. Moots;B. A. Janssen;A. Pall;P. Emery;C. Savage;D. Adu