Sonographic Features of Abscess Maturation in a Porcine Model.
Sonographic Features of Abscess Maturation in a Porcine Model.
复制标题
DOI：
10.1016/j.ultrasmedbio.2021.03.011
复制
发表时间：
2021-07
影响因子：
2.9
通讯作者：
Matula TJ
中科院分区：
文献类型：
--
作者：
Leotta DF;Bruce M;Wang YN;Kucewicz J;Khokhlova T;Chan K;Monsky W;Matula TJ
脓肿是被隔离的被感染的液体聚集，通常在手术和创伤的环境中发展为并发症。治疗通常仅限于经皮插管，并使用一个疗程的抗生素。作为当前治疗策略的替代方案，开发了一种组织摩擦学方法，并在一个新的猪动物模型上进行了测试。目前工作的目标是使用先进的超声成像模式来提取与猪模型中脓肿发展进程相关的超声特征。肌肉内或皮下注射双菌混合物加上葡聚糖颗粒作为刺激物，可在2至3周内导致可识别的脓肿。选择脓肿至少每周行B超、3DB超、剪切波弹性成像(SWE)和平面波多普勒成像。成熟性脓肿的特征是在多普勒成像上有一个清晰的不同回声的核心，周围有一个低回声的包膜，后者是高度血管化的。3D成像显示了脓肿形态的自然历史，脓肿的形状变得不那么复杂，体积增加。此外，随着时间的推移，脓肿变成脓肿，然后液化，SWE表现出僵硬的变化。这些超声特征可能为脓肿治疗策略的选择提供生物标志物。
Abscesses are walled-off collections of infected fluids that often develop as complications in the setting of surgery and trauma. Treatment is usually limited to percutaneous catheterization with a course of antibiotics. As an alternative to current treatment strategies, a histotripsy approach was developed and tested in a novel porcine animal model. The goal of the current work is to use advanced ultrasound imaging modes to extract sonographic features associated with the progression of abscess development in a porcine model. Intramuscular or subcutaneous injections of a bimicrobial bacteria mixture plus dextran particles as an irritant led to identifiable abscesses over a 2- to 3-week period. Selected abscesses were imaged at least weekly with B-mode, 3D B-mode, shear-wave elastography (SWE) and plane-wave Doppler imaging. Mature abscesses were characterized by a well-defined core of varying echogenicity surrounded by a hypoechoic capsule that was highly vascularized on Doppler imaging. 3D imaging demonstrates the natural history of abscess morphology, with the abscess becoming less complex in shape and increasing in volume. Furthermore, SWE demonstrated variations in stiffness as phlegmon becomes abscess and then liquifies, over time. These ultrasound features potentially provide biomarkers to aid selection of treatment strategies for abscesses.
登录
查看更多内容
影响因子：
2.9
作者：
Kunze, Georg;Staritz, Martin;Koehler, Michael
通讯作者：
Koehler, Michael
影响因子：
4.7
作者：
Ripolles, Tomas;Martinez-Perez, Maria J;Blanc, Esther;Delgado, Fructuoso;Vizuete, Jose;Paredes, Jose M;Vilar, Jose
通讯作者：
Vilar, Jose
影响因子：
12.4
作者：
Sigrist RMS;Liau J;Kaffas AE;Chammas MC;Willmann JK
通讯作者：
Willmann JK
影响因子：
3.6
作者：
Mavilia MG;Molina M;Wu GY
通讯作者：
Wu GY
DOI：
10.1016/s0929-8266(98)00065-2
发表时间：
1998-11-01
期刊：
European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology
影响因子：
--
作者：
Arslan, H;Sakarya, M E;Harman, M
通讯作者：
Harman, M