Fracture healing: mechanisms and interventions.
Fracture healing: mechanisms and interventions.
复制标题
DOI：
10.1038/nrrheum.2014.164
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
骨折是人类最常见的大器官创伤。骨折的修复是一个出生后的再生过程，重演了胚胎骨骼发育的许多本体论事件。虽然骨折修复通常将受损的骨骼器官恢复到其损伤前的细胞组成、结构和生物力学功能，但约10%的骨折不会正常愈合。本文从组织、细胞和分子水平综述了骨折愈合的研究进展。先天性和适应性免疫过程作为损伤反应的一个组成部分进行了讨论，因为是环境因素，如骨和周围组织的损伤程度，固定和血管组织的贡献。我们还提出了骨折治疗的策略，这些策略已经在动物模型和临床试验或病例系列中进行了测试。各种治疗方法的分子作用的生物物理和生物学基础，包括重组人骨形态发生蛋白和甲状旁腺激素治疗，也进行了讨论。
Fractures are the most common large-organ, traumatic injuries to humans. The repair of bone fractures is a postnatal regenerative process that recapitulates many of the ontological events of embryonic skeletal development. Although fracture repair usually restores the damaged skeletal organ to its pre-injury cellular composition, structure and biomechanical function, about 10% of fractures will not heal normally. This article reviews the developmental progression of fracture healing at the tissue, cellular and molecular levels. Innate and adaptive immune processes are discussed as a component of the injury response, as are environmental factors, such as the extent of injury to the bone and surrounding tissue, fixation and the contribution of vascular tissues. We also present strategies for fracture treatment that have been tested in animal models and in clinical trials or case series. The biophysical and biological basis of the molecular actions of various therapeutic approaches, including recombinant human bone morphogenetic proteins and parathyroid hormone therapy, are also discussed.
登录
查看更多内容
影响因子：
5.1
作者：
Edwards, PC;Ruggiero, S;Mason, JM
通讯作者：
Mason, JM
影响因子：
5.3
作者：
Barnes, George L.;Kakar, Sanjeev;Einhorn, Thomas A.
通讯作者：
Einhorn, Thomas A.
影响因子：
2.4
作者：
Claes, LE;Heigele, CA
通讯作者：
Heigele, CA
影响因子：
3.7
作者：
Bais M;McLean J;Sebastiani P;Young M;Wigner N;Smith T;Kotton DN;Einhorn TA;Gerstenfeld LC
通讯作者：
Gerstenfeld LC
影响因子：
6.2
作者：
Al-Sebaei, Maisa O.;Daukss, Dana M.;Belkina, Anna C.;Kakar, Sanjeev;Wigner, Nathan A.;Cusher, Daniel;Graves, Dana;Einhorn, Thomas;Morgan, Elise;Gerstenfeld, Louis C.
通讯作者：
Gerstenfeld, Louis C.