Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis.
Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis.
复制标题
作者：
胆碱能抗炎通路是一种基于迷走神经的传出机制，通过α 7烟碱乙酰胆碱受体（α 7 nAChR）信号调节免疫反应和细胞因子的产生。在炎症性肠病（IBD）中观察到传出迷走神经活动减少。我们确定了该通路的中枢激活是否改变了结肠炎小鼠的炎症以及迷走神经-脾脏回路和α 7 nAChR信号传导的介导作用。在C57 BL/6小鼠中使用两种结肠炎实验模型。乙酰胆碱酯酶抑制剂加兰他敏或毒蕈碱型乙酰胆碱受体激动剂治疗诱导的中枢胆碱能激活导致粘膜炎症减轻，与MHC II水平降低和α 7 nAChR信号介导的脾脏CD 11 c+细胞的促炎细胞因子分泌相关。迷走神经切断、脾神经切断或脾切除后，胆碱能抗炎作用消失。总之，中枢胆碱能激活迷走神经脾电路控制肠道炎症，这种调节可以探索开发新的治疗策略。
The cholinergic anti-inflammatory pathway is an efferent vagus nerve-based mechanism that regulates immune responses and cytokine production through α7nicotinic-acetylcholinereceptor (α7nAChR) signaling. Decreased efferent vagus nerve activity is observed in inflammatory bowel disease (IBD). We determined whether central activation of this pathway alters inflammation in mice with colitis and the mediating role of a vagus nerve-to spleen circuit and α7nAChR signaling. Two experimental models of colitis were used in C57BL/6 mice. Central cholinergic activation induced by the acetylcholinesterase inhibitor galantamine or a muscarinic acetylcholine receptor agonist treatments resulted in reduced mucosal inflammation associated with decreased MHC II level and pro-inflammatory cytokine secretion by splenic CD11c+ cells mediated by α7nAChR signaling. The cholinergic anti-inflammatory efficacy was abolished in mice with vagotomy, splenic neurectomy or splenectomy. In conclusion, central cholinergic activation of a vagus nerve–to spleen circuit controls intestinal inflammation and this regulation can be explored to develop novel therapeutic strategies.
登录
查看更多内容
影响因子：
2.7
作者：
Borovikova, LV;Ivanova, S;Tracey, KJ
通讯作者：
Tracey, KJ
DOI：
10.1152/ajpgi.00453.2007
发表时间：
2008-03-01
影响因子：
4.5
作者：
Ghia, Jean-Eric;Galeazzi, Francesca;Collins, Stephen
通讯作者：
Collins, Stephen
影响因子：
6.1
作者：
Ikeda, Y;Ueno, A;Oh-ishi, S
通讯作者：
Oh-ishi, S
DOI：
10.1073/pnas.0708469104
发表时间：
2007-10-23
影响因子：
11.1
作者：
Abe, Kazumichi;Nguyen, Kim Phung;Raz, Eyal
通讯作者：
Raz, Eyal
影响因子：
4.7
作者：
BICKEL, U;THOMSEN, T;KEWITZ, H
通讯作者：
KEWITZ, H