Membrane mimetic surface functionalization of nanoparticles: methods and applications.
Membrane mimetic surface functionalization of nanoparticles: methods and applications.
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DOI：
10.1016/j.cis.2013.04.003
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发表时间：
2013-09
影响因子：
15.6
通讯作者：
Sun XL
中科院分区：
文献类型：
--
作者：
Weingart J;Vabbilisetty P;Sun XL
在过去的几十年里，纳米粒子(NPs)因其尺寸相关的物理和化学性质而显示出巨大的潜力，具有广泛的应用前景。特别是，纳米粒子的生物相容性和功能已被广泛研究，以扩大其在生物成像、生物传感和药物传递等领域的应用潜力。在这样做的过程中，通过引入合成配体和/或天然生物分子来使NPs表面功能化已成为影响NP系统预期用途的整体性能的关键组成部分。在已知的表面功能化的例子中，基于磷脂的人工细胞膜结构的构建已被证明在提高生物相容性方面是有效的，并已成为一种可行的替代更传统的修饰，如直接聚合物偶联。此外，某些生物活性分子可以固定在磷脂平台的表面上，以产生更令人想起细胞表面成分的展示。因此，具有膜模拟显示的纳米颗粒在生物成像、生物传感和药物输送等领域中得到了广泛的应用。本文综述了人工细胞膜结构覆盖的集成功能纳米粒子的制备、表征及其在生物医学中的应用研究进展。
Nanoparticles (NPs), due to their size-dependent physical and chemical properties, have shown remarkable potential for a wide range of applications over the past decades. Particularly, the biological compatibilities and functions of NPs have been extensively studied for expanding their potential in areas of biomedical application such as bioimaging, biosensing, and drug delivery. In doing so, surface functionalization of NPs by introducing synthetic ligands and/or natural biomolecules has become a critical component in regards to the overall performance of the NP system for its intended use. Among known examples of surface functionalization, the construction of an artificial cell membrane structure, based on phospholipids, has proven effective in enhancing biocompatibility and has become a viable alternative to more traditional modifications, such as direct polymer conjugation. Furthermore, certain bioactive molecules can be immobilized onto the surface of phospholipid platforms to generate displays more reminiscent of cellular surface components. Thus, NPs with membrane-mimetic displays have found use in a range of bioimaging, biosensing, and drug delivery applications. This review herein describes recent advances in the preparations and characterization of integrated functional NPs covered by artificial cell membrane structures and their use in various biomedical applications.
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影响因子：
17.1
作者：
Ashley CE;Carnes EC;Epler KE;Padilla DP;Phillips GK;Castillo RE;Wilkinson DC;Wilkinson BS;Burgard CA;Kalinich RM;Townson JL;Chackerian B;Willman CL;Peabody DS;Wharton W;Brinker CJ
通讯作者：
Brinker CJ
影响因子：
3.9
作者：
Bagwe, RP;Hilliard, LR;Tan, WH
通讯作者：
Tan, WH
影响因子：
13.3
作者：
Ahmed, Selver;Savarala, Sushma;Wunder, Stephanie L.
通讯作者：
Wunder, Stephanie L.
影响因子：
5.4
作者：
Galloway, Justin F.;Winter, Alan;Lee, Kwan Hyi;Park, Jea Ho;Dvoracek, Charlene M.;Devreotes, Peter;Searson, Peter C.
通讯作者：
Searson, Peter C.
影响因子：
10.8
作者：
Cauda, Valentina;Engelke, Hanna;Bein, Thomas
通讯作者：
Bein, Thomas