The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs.
The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs.
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DOI：
10.1111/jvim.16131
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发表时间：
2021-05
影响因子：
2.6
通讯作者：
Domenech O
中科院分区：
文献类型：
--
作者：
Vezzosi T;Grosso G;Tognetti R;Meucci V;Patata V;Marchesotti F;Domenech O
基于常规获得的超声心动图变量，黏液瘤性二尖瓣疾病（MMVD）没有共同的严重程度评分。提出一种易于使用的犬MMVD严重程度超声心动图分类方法。560只狗患有MMVD。这是一项回顾性、多中心、观察性研究。所提出的二尖瓣功能不全超声心动图（MINE）评分基于4个超声心动图变量：左心房与主动脉比值、左心室舒张末期直径与体重归一化、缩短分数和E波透射峰速度。根据先前的MMVD预后研究确定具体的超声心动图截止点，并将严重程度评分如下：轻度（评分：4‐5）、中度（评分：6‐7）、重度（评分：8‐12）、晚期（评分：13‐14）。中位生存时间差异有统计学意义(P <。05)，分别为轻度（2344天，95%可信区间[CI] 1877 ~ 2810天）、中度（1882天，95% CI 1341 ~ 2434天）、重度（623天，95% CI 432 ~ 710天）和晚期（157天，95% CI 53 ~ 257天）。MINE评分bb0.8可预测心源性死亡（曲线下面积= 0.85;P < 0.0001；敏感性87%，特异性73%）。在多变量分析中，MINE评分的所有超声心动图变量都是心脏病死亡的独立预测因子（P < 0.001）。MINE评分是一种新的易于使用的MMVD严重程度超声心动图分类，已被证明是临床有效的，因为它与生存有关。这种分类提供了预后信息，可用于MMVD的客观超声心动图评估。
There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables. To propose an easy‐to‐use echocardiographic classification of severity of MMVD in dogs. Five hundred and sixty dogs with MMVD. This was a retrospective, multicenter, observational study. The proposed Mitral INsufficiency Echocardiographic (MINE) score was based on 4 echocardiographic variables: left atrium‐to‐aorta ratio, left ventricular end‐diastolic diameter normalized for body weight, fractional shortening, and E‐wave transmitral peak velocity. Specific echocardiographic cutoffs were defined based on previous prognostic studies on MMVD, and severity scores were assigned as follows: mild (score: 4‐5), moderate (score: 6‐7), severe (score: 8‐12), late stage (score: 13‐14). Median survival time was significantly different (P < .05) between the proposed severity classes: mild (2344 days, 95% confidence interval [CI] 1877‐2810 days), moderate (1882 days, 95% CI 1341‐2434 days), severe (623 days, 95% CI 432‐710 days), and late stage (157 days, 95% CI 53‐257 days). A MINE score >8 was predictive of cardiac death (area under the curve = 0.85; P < .0001; sensitivity 87%, specificity 73%). In the multivariable analysis, all the echocardiographic variables of the MINE score were independent predictors of death because of heart disease (P < .001). The MINE score is a new easy‐to‐use echocardiographic classification of severity of MMVD, which has been proven to be clinically effective as it is associated with survival. This classification provides prognostic information and could be useful for an objective echocardiographic assessment of MMVD.
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影响因子：
2.6
作者：
Larouche-Lebel, Eva;Loughran, Kerry A.;Oyama, Mark A.
通讯作者：
Oyama, Mark A.
影响因子：
2.6
作者：
Di Marcello M;Terzo E;Locatelli C;Palermo V;Sala E;Dall'Aglio E;Bussadori CM;Spalla I;Brambilla PG
通讯作者：
Brambilla PG
影响因子：
2.6
作者：
Acierno, Mark J.;Brown, Scott;Syme, Harriet M.
通讯作者：
Syme, Harriet M.
影响因子：
1.2
作者：
Hezzell, Melanie J.;Boswood, Adrian;Elliott, Jonathan
通讯作者：
Elliott, Jonathan
DOI：
10.1016/j.jvc.2011.08.003
发表时间：
2011-12-01
期刊：
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
影响因子：
--
作者：
Paiva, Rodrigo M P;Garcia-Guasch, Lain;Montoya-Alonso, Jose Alberto
通讯作者：
Montoya-Alonso, Jose Alberto