The multifunctional Prussian blue/graphitic carbon nitride nanocomposites for fluorescence imaging-guided photothermal and photodynamic combination therapy.
The multifunctional Prussian blue/graphitic carbon nitride nanocomposites for fluorescence imaging-guided photothermal and photodynamic combination therapy.
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癌症已被认为是世界范围内最难治的疾病之一，威胁着人类的健康和生命。光热/光动力疗法（Photothermal/Photodynamic Therapy，PTT和PDT）具有无创、副作用小、治疗效率高等优点，已成为肿瘤治疗中可靠、有效的方法。利用普鲁士蓝纳米粒子（PBNPs）与石墨碳氮化物（g-C3 N4）之间的静电相互作用制备了纳米复合材料（PBCN），所得PBCN在808 nm的光照射下具有良好的光热性能和优异的光动力学效应。此外，它在细胞中表现出优异的荧光成像能力，突出了其作为生物医学领域强大成像剂的潜力。因此，与光热材料、光敏剂和荧光成像剂的组合将允许PBCN实现荧光成像引导的PTT/PDT，对癌细胞显示出突出的治疗诊断效果。利用普鲁士蓝纳米粒子与石墨化氮化碳之间的静电相互作用制备了多功能PBCN纳米复合材料，实现了荧光成像引导的光热治疗（PTT）和光动力治疗（PDT）。
Cancer has been regarded as one of the most intractable diseases worldwide and threatens human health and life. Photothermal/Photodynamic therapy (PTT and PDT) have emerged as reliable and effective strategies in cancer treatment with the superiorities of non-invasiveness, slight side effects, and high treatment efficiency. Herein, a nanocomposite (PBCN) was fabricated via electrostatic interaction between Prussian blue nanoparticles (PBNPs) and graphitic carbon nitride (g-C3N4), and the resulting PBCN possessed good photothermal properties and excellent photodynamic effects with 808 nm irradiation. Furthermore, it exhibits excellent fluorescence imaging ability in cells, highlighting its potential as a powerful imaging agent in the biomedical field. Combination with a photothermal material, photosensitizer, and fluorescence imaging agent would thus allow PBCN to realize fluorescence imaging-guided PTT/PDT, showing an outstanding theranostic effect on cancer cells. Multifunctional PBCN nanocomposites were fabricated via electrostatic interaction between Prussian blue nanoparticles and graphitic carbon nitride to realize fluorescence imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT).
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由硼酸修饰的 g-C3N4 支持的普鲁士蓝纳米杂化物，用于细胞表面唾液酸的拉曼识别和光热/光动力治疗
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