Stem cell factor regulates the melanocyte cytoskeleton.
Stem cell factor regulates the melanocyte cytoskeleton.
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干细胞因子调节黑素细胞的细胞骨架。
DOI：
10.1111/j.1600-0749.1996.tb00101.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Luthra,D
中科院分区：
文献类型：
--
作者：
Scott,G;Liang,H;Luthra,D
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Stem cell factor is a growth factor for normal human melanocytes, that acts through the tyrosine kinase receptorc‐kit.We have previously demonstrated that stem cell factor increases melanocyte adhesion and migration on fibronectin, and regulates integrin protein expression. In this report, we have characterized the effect of stem cell factor on the organization of the actin cytoskeleton in human melanocytes attached to fibronectin, and have examined the effect of stem cell factor on the phosphorylation of the focal contact protein paxillin and on the expression of the focal contact proteins talin, paxillin, vinculin, and α‐actinin. Paxillin is a vinculin‐binding protein that is a substrate of focal adhesion kinase, a nonreceptor tyrosine kinase, and in its phosphorylated form is believed to stabilize focal contacts. We show that stem cell factor induces a rapid increase in actin stress fiber formation in melanocytes, which can be abrogated by genistein, a tyrosine kinase inhibitor, and that stem cell factor induces phosphorylation of paxillin on tyrosine residues. In contrast, stem cell factor did not regulate expression of any of the four focal contact proteins tested. These findings have implications for the models describing the mechanisms of action of stem cell factor on melanocyte adhesion and migration, and suggest that reorganization of the cytoskeleton is a primary effect of stem cell factor on human melanocytes.
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人类胚胎和胎儿皮肤中的黑素细胞：回顾和新发现
DOI：
--
发表时间：
1988
期刊：
影响因子：
--
作者：
K. Holbrook;A. Vogel;R. Underwood;C. A. Foster
通讯作者：
C. A. Foster
影响因子：
7.8
作者：
Turner, C E;Glenney, J R Jr;Burridge, K
通讯作者：
Burridge, K
影响因子：
10.5
作者：
NOCKA, K;MAJUMDER, S;BESMER, P
通讯作者：
BESMER, P
PKC 介导 B16a 黑色素瘤细胞中 12(S)-HETE 诱导的细胞骨架重排。
影响因子：
--
作者：
Timar,J;Tang,D;Bazaz,R;Haddad,MM;Kimler,VA;Taylor,JD;Honn,KV
通讯作者：
Honn,KV
影响因子：
4.8
作者：
KNIGHT, JB;YAMAUCHI, K;PESSIN, JE
通讯作者：
PESSIN, JE