Regeneration: The origin of cancer or a possible cure?

Regeneration: The origin of cancer or a possible cure?
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DOI:
10.1016/j.semcdb.2009.04.005
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发表时间:
2009-07
影响因子:
7.3
通讯作者:
Beane WS
Beane WS
中科院分区:
生物学2区
文献类型:
--
作者:
Oviedo NJ;Beane WS

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更好地了解控制细胞生长的力量对于开发再生医学和癌症的有效疗法至关重要。从历史上看,文献将癌症和组织再生联系起来,提出再生既是癌症的来源,也是抑制肿瘤发生的方法。本文综述了两个强大的再生模型,脊椎动物有尾目两栖动物和无脊椎动物的Planarians,在光的癌症调控。有尾目肢体和眼睛透镜再生的描述,以及作为一个分子和遗传模型系统,最近的见解开始分子解剖癌症和再生成人组织中的涡虫的出现。
A better understanding of the forces controlling cell growth will be essential for developing effective therapies in regenerative medicine and cancer. Historically, the literature has linked cancer and tissue regeneration—proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate planarians, in light of cancer regulation. Urodele limb and eye lens regeneration is described, as well as the planarian’s emergence as a molecular and genetic model system in which recent insights begin to molecularly dissect cancer and regeneration in adult tissues.
DOI: 10.1002/jez.1402400210
发表时间: 1986-11-01
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