Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study.
Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study.
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DOI：
10.1111/j.1369-1600.2010.00242.x
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发表时间：
2010-10
影响因子：
3.4
通讯作者：
Veltman DJ
中科院分区：
文献类型：
--
作者：
Goudriaan AE;de Ruiter MB;van den Brink W;Oosterlaan J;Veltman DJ
异常的线索反应是成瘾的一个中心特征，与动机、注意力和记忆相关的脑回路的活动增加有关。在这项神经影像学研究中，问题赌徒（PRG）的线索反应与重度吸烟者（HSM）和健康对照（HC）的线索反应进行了比较。一个功能性磁共振成像事件相关的线索反应范式，赌博，吸烟相关的和中性的图片组成，在17个寻求治疗的非吸烟PRG，18个非赌博的HSM，和17个非赌博和非吸烟的HC。观看赌博图片（相对于中性图片）与PRG的枕颞区、后扣带回、海马旁回和杏仁核的脑激活程度高于HC和HSM。PRG的主观渴求与左腹外侧前额叶皮层和左额叶皮层的激活呈正相关。当将高血压组与其他两组进行比较时，没有发现吸烟线索诱导的大脑活动有显著差异。在分层分析中，具有较高的尼古丁依赖性分数的高血压亚组（FTND M = 5.4）显示腹内侧前额叶皮层，头端前扣带皮层，在观看与吸烟相关的图片（相对于中性图片）时，与具有较低FTND评分（FTND M = 2.9）的HSM亚组和不吸烟HC相比，颞中回和中/上级颞上回（相对于中性图片）。当观看与吸烟相关的图片时，吸烟渴求与左前额叶和左杏仁核的激活相关。在PRG中，与动机和视觉处理相关的大脑区域对赌博图片的区域反应性增加，类似于物质依赖中的潜在线索反应性的神经机制。与FTND分数较低的HSM相比，FTND分数较高的HSM中相关额边缘脑区的脑激活增加。
Abnormal cue reactivity is a central characteristic of addiction, associated with increased activity in motivation, attention and memory related brain circuits. In this neuroimaging study, cue reactivity in problem gamblers (PRG) was compared with cue reactivity in heavy smokers (HSM) and healthy controls (HC). A functional magnetic resonance imaging event-related cue reactivity paradigm, consisting of gambling, smoking-related and neutral pictures, was employed in 17 treatment-seeking non-smoking PRG, 18 non-gambling HSM, and 17 non-gambling and non-smoking HC. Watching gambling pictures (relative to neutral pictures) was associated with higher brain activation in occipitotemporal areas, posterior cingulate cortex, parahippocampal gyrus and amygdala in PRG compared with HC and HSM. Subjective craving in PRG correlated positively with brain activation in left ventrolateral prefrontal cortex and left insula. When comparing the HSM group with the two other groups, no significant differences in brain activity induced by smoking cues were found. In a stratified analysis, the HSM subgroup with higher Fagerström Test for Nicotine Dependence scores (FTND M = 5.4) showed higher brain activation in ventromedial prefrontal cortex, rostral anterior cingulate cortex, insula and middle/superior temporal gyrus while watching smoking-related pictures (relative to neutral pictures) than the HSM subgroup with lower FTND scores (FTND M = 2.9) and than non-smoking HC. Nicotine craving correlated with activation in left prefrontal and left amygdala when viewing smoking-related pictures in HSM. Increased regional responsiveness to gambling pictures in brain regions linked to motivation and visual processing is present in PRG, similar to neural mechanisms underlying cue reactivity in substance dependence. Increased brain activation in related fronto-limbic brain areas was present in HSM with higher FTND scores compared with HSM with lower FTND scores.
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