Genetic analysis of NHLH2 and its putative role in bovine body weight control.
Genetic analysis of NHLH2 and its putative role in bovine body weight control.
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NHLH2 的遗传分析及其在牛体重控制中的假定作用。
DOI：
10.1111/j.1365-2052.2006.01474.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Good,DJ
中科院分区：
文献类型：
--
作者：
Brennan,KM;Vella,KR;Good,DJ
The control of energy balance is fundamental to adult animals and is necessary for weight gain/loss, reproductive capacity and general health. In mice, targeted deletion of the neuronal transcription factor Nhlh2 results in adult‐onset obesity because of reduced exercise and infertility because of reduced sexual behaviour. Nhlh2 (NHLH2 for humans) is expressed in the hypothalamus, particularly in neurons that have been shown to regulate energy balance. We have cloned the bovine Nhlh2 gene (bNHLH2) and we have shown that bNHLH2 is also expressed in the hypothalamus. Phylogenetic analysis of Nhlh2 reveals that it is very highly conserved in humans, mice, chimps and cattle, and found in organisms with simpler nervous systems, includingCaenorhabditis elegansandDrosophila. Using a cattle–human comparative map and online databases, we have evidence that bNHLH2 is located near a quantitative trait locus for marbling on bovine chromosome 3 between microsatellite markers BM723 and BMS963. Cloning of the bNHLH2 gene from Holstein cattle and a mixed breed individual and comparison with Hereford sequences shows that the gene is highly conserved among bovine breeds.
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DOI：
10.1016/s0174-173x(85)80034-0
发表时间：
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DOI：
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发表时间：
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DOI：
10.1016/s0021-9258(17)38436-3
发表时间：
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期刊：
The Journal of biological chemistry
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