Respiratory allergy in agricultural workers: recent developments
Respiratory allergy in agricultural workers: recent developments
复制标题
农业工人的呼吸道过敏：最新进展
DOI：
--
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发表时间：
2005
影响因子：
2.8
通讯作者：
T. Sigsgaard
中科院分区：
文献类型：
--
作者：
D. Heederik;T. Sigsgaard
综述的目的：综述最近关于职业暴露于过敏原和哮喘原之间关系的证据，以及农民和农场工人发生过敏和哮喘的风险和修饰因素的作用。最近的发现最近的研究确定了以前在农业人口中与过敏或哮喘无关的药物。然而，最令人感兴趣的发现是那些表明特应性和哮喘的发展可能受到包括内毒素在内的病原体相关分子模式（PAMP）的影响。概述了农场环境中微生物暴露的不利影响和潜在的保护作用。最近的研究结果表明，暴露于PAMP（如内毒素）的保护作用很可能不仅限于儿童年龄。可能在儿童时期形成的保护作用在成年时仍然可以观察到。此外，成年人（在职业环境中）的暴露刺激先天免疫系统，似乎甚至可能对过敏产生影响，而与儿童期的暴露无关。据推测，特应性的逆转可能是由于高暴露于内毒素和其他PAMP的结果。
Purpose of reviewTo review recent evidence on the relationship between occupational exposure to allergens and asthmagens, and risk for developing allergy and asthma and the role of modifying factors in farmers and farm workers. Recent findingsRecent studies identified agents that have not been associated with allergy or asthma in farming populations before. The most intriguing findings, however, are those that suggest that the development of atopy and asthma might be influenced by exposure to pathogen associated molecular patterns (PAMPs), including endotoxin. SummaryThe adverse and potentially protective effects of microbial exposures in the farm environment are discussed. Recent findings indicate that it is very likely that the protective effect of exposure to PAMPs such as endotoxin is not limited to childhood age. The protective effects that probably developed during childhood can still be observed at adult age. Furthermore, it even seems likely that exposures at adult age (in occupational environments), which stimulate the innate immune system, have an effect on allergy, independently of childhood exposure. It is hypothesized that reversal of atopy might occur as a result of high exposure to endotoxins and other PAMPs.
DOI：
10.1164/ajrccm.163.4.2004164
发表时间：
2001-03-01
影响因子：
24.7
作者：
Koppelman, GH;Reijmerink, NE;Bleecker, ER
通讯作者：
Bleecker, ER
房屋和农场谷仓灰尘中的细菌 DNA。
DOI：
10.1016/s0091-6749(03)01863-3
发表时间：
2003
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Roy,SiteshR;Schiltz,AllisonM;Marotta,Alex;Shen,Yiqin;Liu,AndrewH
通讯作者：
Liu,AndrewH
DOI：
10.1164/ajrccm.165.5.2106074
发表时间：
2002-03-01
影响因子：
24.7
作者：
Hoppin, JA;Umbach, DM;Sandler, DP
通讯作者：
Sandler, DP