Neonatal Lipopolysaccharide Exposure Gender-Dependently Increases Heart Susceptibility to Ischemia/Reperfusion Injury in Male Rats.

Neonatal Lipopolysaccharide Exposure Gender-Dependently Increases Heart Susceptibility to Ischemia/Reperfusion Injury in Male Rats.
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DOI:
10.7150/ijms.20285
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发表时间:
2017
影响因子:
3.6
通讯作者:
Xiao D
Xiao D
中科院分区:
医学4区
文献类型:
--
作者:
Zhang P;Lv J;Li Y;Zhang L;Xiao D

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背景资料:在新生儿早期暴露于不利的压力已被证明会导致发育异常,导致成人疾病的风险增加。我们检验了新生儿暴露于脂多糖(LPS)不会改变静息状态下的心脏功能,但会在以后的生活中引起应激刺激下的心脏功能障碍的假设。方法:新生大鼠腹腔注射生理盐水对照组和内毒素组。实验在6周龄的雄性和雌性大鼠中进行。在Langendorff制剂中灌注离体心脏。结果如下:新生儿LPS暴露对发育中大鼠的体重没有影响,但在雄性大鼠中诱导左心室(LV)与体重的比值降低。新生儿LPS暴露显示对体内和离体实验测定的基线心脏功能没有影响,但导致雄性而非雌性大鼠的LV功能缺血后恢复降低。新生儿LPS介导的LV功能障碍与雄性大鼠心肌梗死面积增加和LDH释放相关。结论:目前的研究提供了新的证据,新生儿免疫挑战可能会诱导性别依赖性的心脏发育和心脏功能的长期影响,这加强了这样的概念,即在新生儿早期的不良应激暴露可以加重心脏功能和心脏缺血敏感表型的发展在以后的生活。
Background: Adverse stress exposure during the early neonatal period has been shown to cause aberrant development, resulting in an increased risk of adult disease. We tested the hypothesis that neonatal exposure to lipopolysaccharide (LPS) does not alter heart function at rest condition but causes heart dysfunction under stress stimulation later in life. Methods: Saline control or LPS were administered to neonatal rats via intraperitoneal injection. Experiments were conducted in 6 week-old male and female rats. Isolated hearts were perfused in a Langendorff preparation. Results: Neonatal LPS exposure exhibited no effects on the body weight of the developing rats, but induced decreases in the left ventricle (LV) to the body weight ratio in male rats. Neonatal LPS exposure showed no effects on the baseline heart function determined by in vivo and ex vivo experiments, but caused decreases in the post-ischemic recovery of the LV function in male but not female rats. Neonatal LPS-mediated LV dysfunction was associated with an increase in myocardial infarct size and the LDH release in the male rats. Conclusion: The present study provides novel evidence that neonatal immune challenges could induce gender-dependent long-term effects on cardiac development and heart function, which reinforces the notion that adverse stress exposure during the early neonatal period can aggravate heart functions and the development of a heart ischemia-sensitive phenotype later in life.
DOI: 10.1016/s0140-6736(14)61682-2
发表时间: 2015-01-10
期刊: LANCET
影响因子: 168.9
作者:
Naghavi, Mohsen;Wang, Haidong;Lozano, Rafael;Davis, Adrian;Liang, Xiaofeng;Zhou, Maigeng;Vollset, Stein Emil;Ozgoren, Ayse Abbasoglu;Abdalla, Safa;Abd-Allah, Foad;Aziz, Muna I. Abdel;Abera, Semaw Ferede;Aboyans, Victor;Abraham, Biju;Abraham, Jerry P.;Abuabara, Katrina E.;Abubakar, Ibrahim;Abu-Raddad, Laith J.;Abu-Rmeileh, Niveen M. E.;Achoki, Tom;Adelekan, Ademola;Ademi, Zanfi Na;Adofo, Koranteng;Adou, Arsene Kouablan;Adsuar, Jose C.;Arnlov, Johan;Agardh, Emilie Elisabet;Akena, Dickens;Al Khabouri, Mazin J.;Alasfoor, Deena;Albittar, Mohammed;Alegretti, Miguel Angel;Aleman, Alicia V.;Alemu, Zewdie Aderaw;Alfonso-Cristancho, Rafael;Alhabib, Samia;Ali, Mohammed K.;Ali, Raghib;Alla, Francois;Al Lami, Faris;Allebeck, Peter;AlMazroa, Mohammad A.;Salman, Rustam Al-Shahi;Alsharif, Ubai;Alvarez, Elena;Alviz-Guzman, Nelson;Amankwaa, Adansi A.;Amare, Azmeraw T.;Ameli, Omid;Amini, Hassan;Ammar, Walid;Anderson, H. Ross;Anderson, Benjamin O.;Antonio, Carl Abelardo T.;Anwari, Palwasha;Apfel, Henry;Cunningham, Solveig Argeseanu;Arsenijevic, Valentina S. Arsic;Al Artaman;Asad, Majed Masoud;Asghar, Rana J.;Assadi, Reza;Atkins, Lydia S.;Atkinson, Charles;Badawi, Alaa;Bahit, Maria C.;Bakfalouni, Talal;Balakrishnan, Kalpana;Balalla, Shivanthi;Banerjee, Amitava;Barber, Ryan M.;Barker-Collo, Suzanne L.;Barquera, Simon;Barregard, Lars;Barrero, Lope H.;Barrientos-Gutierrez, Tonatiuh;Basu, Arindam;Basu, Sanjay;Basulaiman, Mohammed Omar;Beardsley, Justin;Bedi, Neeraj;Beghi, Ettore;Bekele, Tolesa;Bell, Michelle L.;Benjet, Corina;Bennett, Derrick A.;Bensenor, Isabela M.;Benzian, Habib;Bertozzi-Villa, Amelia;Beyene, Tariku Jibat;Bhala, Neeraj;Bhalla, Ashish;Bhutta, Zulfiqar A.;Bikbov, Boris;Bin Abdulhak, Aref;Biryukov, Stan;Blore, Jed D.;Blyth, Fiona M.;Bohensky, Megan A.;Borges, Guilherme;Bose, Dipan;Boufous, Soufiane;Bourne, Rupert R.;Boyers, Lindsay N.;Brainin, Michael;Brauer, Michael;Brayne, Carol E. 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通讯作者: Murray, Christopher J. L.
DOI: 10.1111/j.1440-1681.2008.04885.x
发表时间: 2008-04-01
影响因子: 2.9
作者:
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通讯作者: Arnal, J. F.
DOI: 10.1586/ecp.09.11
发表时间: 2009-07-01
影响因子: 4.4
作者:
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通讯作者: Emery, Sean
DOI: 10.1111/j.1749-6632.2010.05798.x
发表时间: 2010-01-01
期刊: YEAR IN DIABETES AND OBESITY
影响因子: --
作者:
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DOI: 10.1113/jphysiol.2005.082701
发表时间: 2005-05-15
影响因子: 5.5
作者:
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通讯作者: Zhang, LB