Recent advances in the prevention and treatment of skin cancer using photodynamic therapy.
Recent advances in the prevention and treatment of skin cancer using photodynamic therapy.
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DOI：
10.1586/era.10.154
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发表时间：
2010-11
影响因子：
3.3
通讯作者：
He YY
中科院分区：
文献类型：
--
作者：
Zhao B;He YY
光动力疗法（PDT）是一种非侵入性的治疗方法，涉及光敏药物及其随后的光激活，以产生特异性破坏靶细胞的活性氧。最近，PDT已被广泛用于治疗非黑色素瘤皮肤恶性肿瘤，这是美国最常见的癌症，与传统疗法相比具有上级美容效果。常用的局部“光敏剂”是5-氨基乙酰丙酸（ALA）及其酯化衍生物5-氨基乙酰丙酸甲酯，它们是内源性光敏剂原卟啉IX的前体。用ALA或5-氨基乙酰丙酸甲酯处理后，原卟啉IX优先在各种皮肤病的病变区域积累，这不仅允许PDT治疗，而且允许用ALA诱导的卟啉进行荧光诊断。易感病变包括各种形式的非黑色素瘤皮肤癌，如光化性角化病、基底细胞癌和鳞状细胞癌。PDT的最新和最有前途的发展包括发现新的光敏剂，开发新的药物输送系统和其他模式的组合，这都将有助于提高PDT的治疗效果和改善结果。本文总结了PDT的主要原理及其在非黑色素瘤皮肤癌治疗中的临床应用，以及最新进展和未来可能的研究方向。
Photodynamic therapy (PDT) is a noninvasive procedure that involves a photosensitizing drug and its subsequent activation by light to produce reactive oxygen species that specifically destroy target cells. Recently, PDT has been widely used in treating non-melanoma skin malignancies, the most common cancer in the USA, with superior cosmetic outcomes compared with conventional therapies. The topical ‘photosensitizers’ commonly used are 5-aminolevulinic acid (ALA) and its esterified derivative methyl 5-aminolevulinate, which are precursors of the endogenous photosensitizer protoporphyrin IX. After treatment with ALA or methyl 5-aminolevulinate, protoporphyrin IX preferentially accumulates in the lesion area of various skin diseases, which allows not only PDT treatment but also fluorescence diagnosis with ALA-induced porphyrins. Susceptible lesions include various forms of non-melanoma skin cancer such as actinic keratosis, basal cell carcinoma and squamous cell carcinoma. The most recent and promising developments in PDT include the discovery of new photosensitizers, the exploitation of new drug delivery systems and the combination of other modalities, which will all contribute to increasing PDT therapeutic efficacy and improving outcome. This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions.
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影响因子：
--
作者：
Cheng, Shih-Hsun;Lee, Chia-Hung;Lo, Leu-Wei
通讯作者：
Lo, Leu-Wei
影响因子：
2.1
作者：
Brancaleon, L;Moseley, H
通讯作者：
Moseley, H
影响因子：
4.9
作者：
Brevet, David;Gary-Bobo, Magali;Durand, Jean-Olivier
通讯作者：
Durand, Jean-Olivier
DOI：
10.1111/j.1440-0960.1998.tb01250.x
发表时间：
1998-05-01
期刊：
The Australasian journal of dermatology
影响因子：
--
作者：
Ball, S B;Dawber, R P
通讯作者：
Dawber, R P
影响因子：
6.5
作者：
de Graaf, Ymke G. L.;Kennedy, Cornelis;Bavinck, Jan N. Bouwes
通讯作者：
Bavinck, Jan N. Bouwes