Collaborative biomedicine in the age of big data: the case of cancer.

Collaborative biomedicine in the age of big data: the case of cancer.
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DOI:
10.2196/jmir.2496
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发表时间:
2014-04-07
影响因子:
7.4
通讯作者:
Hesse BW
Hesse BW
中科院分区:
医学2区
文献类型:
--
作者:
Shaikh AR;Butte AJ;Schully SD;Dalton WS;Khoury MJ;Hesse BW

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生物医学正在经历一场由高吞吐量和连接计算驱动的革命,这场革命正在改变医学研究和实践。以肿瘤学为例,基因组测序技术的速度和能力正在推进个体遗传图谱在预测风险和靶向治疗方面的应用。我们的目标是实现一个“P4”医学时代,随着时间的推移,这个时代将变得越来越具有预测性、个性化、先发制人和参与性。这一愿景取决于利用医学中潜在的创新和颠覆性技术来加速发现并重新定位以患者为中心的临床实践。基于在波士顿举行的医学2.0会议上与来自美国国家癌症研究所、莫菲特癌症中心和斯坦福大学医学院的代表进行的小组讨论,本文探讨了新兴的社会技术框架、信息学平台和健康相关政策如何用于鼓励数据流动性和创新。这建立在医学研究所的“快速学习医疗保健系统”的愿景基础上,以实现开源,基于人群的癌症预防和控制方法。
Biomedicine is undergoing a revolution driven by high throughput and connective computing that is transforming medical research and practice. Using oncology as an example, the speed and capacity of genomic sequencing technologies is advancing the utility of individual genetic profiles for anticipating risk and targeting therapeutics. The goal is to enable an era of “P4” medicine that will become increasingly more predictive, personalized, preemptive, and participative over time. This vision hinges on leveraging potentially innovative and disruptive technologies in medicine to accelerate discovery and to reorient clinical practice for patient-centered care. Based on a panel discussion at the Medicine 2.0 conference in Boston with representatives from the National Cancer Institute, Moffitt Cancer Center, and Stanford University School of Medicine, this paper explores how emerging sociotechnical frameworks, informatics platforms, and health-related policy can be used to encourage data liquidity and innovation. This builds on the Institute of Medicine’s vision for a “rapid learning health care system” to enable an open source, population-based approach to cancer prevention and control.
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