Clinicopathological Features of Stage I-III Colorectal Cancer Recurrence Over 5 Years After Radical Surgery Without Receiving Neoadjuvant Therapy: Evidence From a Large Sample Study.
Clinicopathological Features of Stage I-III Colorectal Cancer Recurrence Over 5 Years After Radical Surgery Without Receiving Neoadjuvant Therapy: Evidence From a Large Sample Study.
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DOI：
10.3389/fsurg.2021.666400
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发表时间：
2021
影响因子：
1.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Luo D;Yang Y;Shan Z;Liu Q;Cai S;Li Q;Li X
结直肠癌根治性切除后晚期复发（5年或更长时间）是罕见的。本研究旨在探讨I-III期结直肠癌晚期复发的特点。本研究共纳入9754例在复旦大学上海肿瘤中心（FUSCC）接受根治性手术而未接受新辅助治疗的I-III期结直肠癌患者。这些患者分为三组：早期复发（3个月~ 2年）、中期复发（2 - 5年）和晚期复发（5年以上）。中位随访时间为53.5±30.1个月。共有2341例（24.0%）患者出现复发。晚期复发率为11.7%。晚期复发风险越高的患者，年龄越大，T4期越高，结肠癌程度越高，印戒细胞癌发生频率越低，低分化肿瘤越少，结直肠癌早期越少，周围神经和血管侵犯越少。多因素logistic回归分析发现，年龄、分化、T分期、N分期、神经周围和血管浸润是晚期复发的独立因素。晚期复发性结直肠癌有一些独特的特点。虽然术后5年以上的复发并不常见，但仍需要对5年后的患者进行加强随访。
Late recurrence (5 or more years) after radical resection of colorectal cancer (CRC) is rare. This study aims to investigate the features of late recurrence in stage I–III CRC. A total of 9,754 stage I–III patients with CRC who underwent radical surgery without receiving neoadjuvant therapy, at the Fudan University Shanghai Cancer Center (FUSCC), were enrolled in this study. These patients were divided into three groups: early recurrence (3 months−2 years), intermediate recurrence (2–5 years), and late recurrence (over 5 years). The median duration of follow-up was 53.5 ± 30.1 months. A total of 2,341 (24.0%) patients developed recurrence. The late recurrence rate was 11.7%. Patients with a higher risk of late recurrence were more likely to be older, to be at the T4 stage, to have a higher degree of colon cancer, to have a lower frequency of signet ring cell carcinoma, to have fewer poorly differentiated tumors, to be at the early stage of CRC, along with less perineural and vascular invasions. Multivariate logistic regression analysis identified age, differentiation, T stage, N stage, perineural, and vascular invasions as independent factors for late recurrence. Late recurrent CRC has some distinctive characteristics. Although recurrence over 5 years after surgery is infrequent, an enhanced follow-up is still needed for the selected patients after 5 years.
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影响因子：
2.5
作者：
Seo, Seok In;Lim, Seok-Byung;Kim, Jin Cheon
通讯作者：
Kim, Jin Cheon
影响因子：
3.7
作者：
Lee Y;Song B;Park C;Kwon KS
通讯作者：
Kwon KS
自噬相关特征对 I-III 期结肠癌早期复发的预后和预测价值
影响因子：
4.7
作者：
Mo, Shaobo;Dai, Weixing;Cai, Guoxiang
通讯作者：
Cai, Guoxiang
影响因子：
8.8
作者：
Broadbridge, V. T.;Karapetis, C. S.;Price, T. J.
通讯作者：
Price, T. J.
影响因子：
5.6
作者：
Knijn, Nikki;Mogk, Stephanie C.;Nagtegaal, Iris D.
通讯作者：
Nagtegaal, Iris D.