Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.
Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.
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DOI：
10.3892/mmr.2015.3480
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发表时间：
2015-07
影响因子：
3.4
通讯作者：
Ko SG
中科院分区：
文献类型：
--
作者：
Seo HS;Woo JK;Shin YC;Ko SG
类维生素a具有抗增殖特性，这表明它们具有化学预防和治疗癌症的潜力。在目前的研究中，rexinoids (retinoid X receptor (RXR)-pan激动剂，LGD1069和LG100268；利用Affymetrix微阵列在正常和恶性乳腺细胞中鉴定RXRα激动剂Ro25-7386)。观察到LGD1069、LG100268和Ro25-7386对乳腺细胞的生长有抑制作用。其次，确定了几个类肾上腺素调节基因，这些基因参与细胞死亡、细胞生长/维持、信号转导和对刺激的反应。这些基因可能与类维生素a的生长抑制活性有关。因此，所鉴定的基因可能作为预防和治疗乳腺癌的生物标志物和新的分子靶点。
Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.
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影响因子：
7.5
作者：
LOVE, JM;GUDAS, LJ
通讯作者：
GUDAS, LJ
DOI：
10.1186/bcr913
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Crowe DL;Chandraratna RA
通讯作者：
Chandraratna RA
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
254.7
作者：
DeSantis, Carol;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
8
作者：
Ma, Y;Koza-Taylor, PH;Dmitrovsky, E
通讯作者：
Dmitrovsky, E