Long-term ozone exposure and lung function in middle childhood.
Long-term ozone exposure and lung function in middle childhood.
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长期臭氧暴露与儿童中期的肺功能。
DOI：
10.1016/j.envres.2023.117632
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发表时间：
2024
影响因子：
8.3
通讯作者：
Karr,C
中科院分区：
文献类型：
--
作者：
Hazlehurst,MarnieF;Dearborn,LoganC;Sherris,AllisonR;Loftus,ChristineT;Adgent,MargaretA;Szpiro,AdamA;Ni,Yu;Day,DrewB;Kaufman,JoelD;Thakur,Neeta;Wright,RosalindJ;Sathyanarayana,Sheela;Carroll,KeciaN;Moore,PaulE;Karr,C
背景臭氧 (O3) 暴露会中断动物模型中的正常肺部发育。流行病学证据进一步表明，儿童早期和中期较高的长期 O3 暴露会造成损害，尽管迄今为止的研究结果参差不齐，而且很少有人调查易受影响的亚群体。 方法 CANDLE 研究是 ECHO-PATHWAYS 联盟中田纳西州谢尔比县的一个妊娠队列，如果儿童出生时胎龄 > 32 周，在 8-9 岁时完成了肺量测定检查，并且从出生到8 岁。我们根据每个孩子从出生到 8 岁的居住史，使用经过验证的精细分辨率时空模型估算了终生平均环境 O3 暴露量。在 8-9 岁研究访视时进行肺活量测定，以评估第一秒用力呼气量 (FEV1) 和用力肺活量 (FVC) 作为主要结果； z 分数是使用特定性别和年龄的参考方程计算的。使用具有稳健方差估计量的线性回归来检查 O3 暴露与连续肺功能 z 评分之间的关联，并根据儿童、社会人口统计和家庭环境因素进行调整。使用回归模型中的乘积项探索潜在的易感亚组，以评估儿童性别、婴儿期细支气管炎病史和过敏致敏的影响修正。结果在我们的样本 (n = 648) 中，从出生到 8 岁的平均 O3 暴露量适中（平均值 26.6 [SD 1.1] ppb）。未观察到出生后长期 O3 暴露与 FEV1（β = 0.12，95% CI：-0.04，0.29）或 FVC（β = 0.03，95% CI：-0.13，0.19）之间的不良关联。未检测到儿童性别、婴儿期细支气管炎病史或过敏致敏与 8 年平均 O3 的相关性。结论在这个 O3 浓度较低的样本中，我们没有观察到从出生到 8 岁平均 O3 暴露与儿童中期肺功能之间的不利关联。
BackgroundOzone (O3) exposure interrupts normal lung development in animal models. Epidemiologic evidence further suggests impairment with higher long-term O3exposure across early and middle childhood, although study findings to date are mixed and few have investigated vulnerable subgroups.MethodsParticipants from the CANDLE study, a pregnancy cohort in Shelby County, TN, in the ECHO-PATHWAYS Consortium, were included if children were born at gestational age >32 weeks, completed a spirometry exam at age 8–9, and had a valid residential history from birth to age 8. We estimated lifetime average ambient O3exposure based on each child's residential history from birth to age 8, using a validated fine-resolution spatiotemporal model. Spirometry was performed at the age 8–9 year study visit to assess Forced Expiratory Volume in the first second (FEV1) and Forced Vital Capacity (FVC) as primary outcomes; z-scores were calculated using sex-and-age-specific reference equations. Linear regression with robust variance estimators was used to examine associations between O3exposure and continuous lung function z-scores, adjusted for child, sociodemographic, and home environmental factors. Potential susceptible subgroups were explored using a product term in the regression model to assess effect modification by child sex, history of bronchiolitis in infancy, and allergic sensitization.ResultsIn our sample (n = 648), O3exposure averaged from birth to age 8 was modest (mean 26.6 [SD 1.1] ppb). No adverse associations between long-term postnatal O3exposure were observed with either FEV1(β = 0.12, 95% CI: −0.04, 0.29) or FVC (β = 0.03, 95% CI: −0.13, 0.19). No effect modification by child sex, history of bronchiolitis in infancy, or allergic sensitization was detected for associations with 8-year average O3.ConclusionsIn this sample with low O3concentrations, we did not observe adverse associations between O3exposures averaged from birth to age 8 and lung function in middle childhood.
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DOI：
10.1164/ajrccm.159.3.9804144
发表时间：
1999-03-01
影响因子：
24.7
作者：
Peters, JM;Avol, E;Thomas, DC
通讯作者：
Thomas, DC
影响因子：
4.4
作者：
Wickman, M;Ahlstedt, S;Hamsten, MV
通讯作者：
Hamsten, MV
DOI：
10.1016/j.ijheh.2015.07.003
发表时间：
2015-10-01
影响因子：
6
作者：
Fuertes, Elaine;Bracher, Johannes;Schulz, Holger
通讯作者：
Schulz, Holger
FEF25-75 中的支气管扩张剂反应用于诊断儿童哮喘
影响因子：
2.5
作者：
Marcela B Linares;María Angelica Rodríguez;Danae M Icarte;Bitter A Martínez;Valentina P Milla;Noelia F Zygier;Claudio R Olmos
通讯作者：
Claudio R Olmos
影响因子：
8.3
作者：
Bougas, Nicolas;Ranciere, Fanny;Momas, Isabelle
通讯作者：
Momas, Isabelle