Potential association of anticholinergic medication intake and caries experience in young adults with xerostomia.
Potential association of anticholinergic medication intake and caries experience in young adults with xerostomia.
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DOI：
10.1016/j.jds.2023.01.019
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发表时间：
2023-10
影响因子：
3.5
通讯作者：
Arany, Szilvia
中科院分区：
文献类型：
--
作者：
Kakkar, Mayank;de Souza Valentim, Estela Caetano;Barmak, Abdul Basir;Arany, Szilvia
越来越多的抗胆碱能药物处方对口腔健康有着至关重要的影响。在老年人群中，抗胆碱能药物诱导的口干症（口腔干燥的主观感觉）与高龋齿、缺失和填充牙齿（DMFT）指数之间存在联系。这项回顾性研究的目的是确定18-44岁成人中最常用的抗胆碱能药物的暴露和患病率，以及探讨口干症及其与龋齿状况的关系。我们对2019年1月至2010年4月期间在纽约州罗切斯特的伊士曼口腔健康研究所（EIOH）接受牙科检查的18至44岁成人进行了一项回顾性研究。我们回顾了236位成人口腔干燥症患者的电子牙科图表和医疗记录。71%的口干症患者至少服用了五种或五种以上的药物，85%的患者至少服用了一种抗胆碱能药物。平均抗胆碱能药物评分（ADS）为2.93。我们发现全身状况如心脏、神经和睡眠呼吸暂停通过预测龋齿状态影响DMFT指数（P < 0.001）。年轻人的抗胆碱能药物暴露和药物诱导的口干症与龋齿有关，需要复杂的跨学科治疗。
Growing prescription of anticholinergic medications has a critical effect on oral health. A link between anticholinergic medication-induced xerostomia (subjective feeling of oral dryness) and a high Decayed, Missing, and Filled teeth (DMFT) index has been reported in the older population. The purpose of this retrospective study is to determine anticholinergic exposure and prevalence of the most frequently used anticholinergic medications in adults 18–44 years of age, as well as to explore xerostomia and its association with caries status. We performed a retrospective study of adults between the age of 18 and 44 years who received a dental examination between January 2019 and April 2010, at Eastman Institute for Oral Health (EIOH), Rochester, NY. We reviewed the electronic dental charts and medical records of 236 adults with xerostomia. 71% of young adults with xerostomia were prescribed at least five or more medications (polypharmacy), and 85% took at least one anticholinergic drug. The average anticholinergic drug scale (ADS) was 2.93. We found systemic conditions such as cardiac, neurological, and sleep apnea affecting the DMFT index by predicting the caries status (P < 0.001). Anticholinergic exposure and medication-induced xerostomia in younger adults are associated with dental caries and require complex interdisciplinary therapy.
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DOI：
10.1016/j.oooo.2021.08.015
发表时间：
2021-12
影响因子：
2.9
作者：
Arany, Szilvia;Kopycka-Kedzierawski, Dorota T.;Caprio, Thomas, V;Watson, Gene E.
通讯作者：
Watson, Gene E.
影响因子：
2
作者：
Tanner, Tarja;Kamppi, Antti;Anttonen, Vuokko
通讯作者：
Anttonen, Vuokko
影响因子：
4.6
作者：
Cebron Lipovec, Nanca;Jazbar, Janja;Kos, Mitja
通讯作者：
Kos, Mitja
影响因子：
2
作者：
Kongstad, Johanne;Ekstrand, Kim;Fiehn, Nils-Erik
通讯作者：
Fiehn, Nils-Erik
影响因子：
1.9
作者：
Lopes, Alexandre Gomes;Ju, Xiangqun;Mialhe, Fabio Luiz
通讯作者：
Mialhe, Fabio Luiz