Carbohydrates and T cells: a sweet twosome.
Carbohydrates and T cells: a sweet twosome.
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DOI：
10.1016/j.smim.2013.05.005
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发表时间：
2013-04
影响因子：
7.8
通讯作者：
Kasper DL
中科院分区：
文献类型：
--
作者：
Avci FY;Li X;Tsuji M;Kasper DL
碳水化合物作为T细胞活化抗原已经引起了极大的兴趣。多年来，碳水化合物被认为是T-非依赖性抗原，然而，最近的研究表明，与肽糖苷连接的单糖或寡糖可以被T细胞识别。T细胞对这些糖肽的识别取决于抗原的肽和聚糖部分的结构。随后，发现自然杀伤T细胞在由抗原呈递分子CD 1d呈递时识别糖脂。当两性离子多糖被发现与CD 4 + T细胞结合并被MHCII呈递给CD 4 + T细胞时，T细胞对聚糖识别的一个变革性见解发生了。基于后一种观察，探索了由糖缀合物疫苗产生的碳水化合物表位在活化辅助T细胞中的作用，并且发现这些表位通过独特的机制呈递给特异性碳水化合物识别T细胞。在这里，我们回顾了碳水化合物抗原和适应性免疫系统在分子，细胞和系统水平上的关键相互作用，探索健康和疾病的重要生物学意义。
Carbohydrates as T cell-activating antigens have been generating significant interest. For many years, carbohydrates were thought of as T-independent antigens, however, more recent research had demonstrated that mono- or oligosaccharides glycosidically-linked to peptides can be recognized by T cells. T cell recognition of these glycopeptides depends on the structure of both peptide and glycan portions of the antigen. Subsequently, it was discovered that natural killer T cells recognized glycolipids when presented by the antigen presenting molecule CD1d. A transformative insight into glycan-recognition by T cells occurred when zwitterionic polysaccharides were discovered to bind to and be presented by MHCII to CD4+ T cells. Based on this latter observation, the role that carbohydrate epitopes generated from glycoconjugate vaccines had in activating helper T cells was explored and it was found that these epitopes are presented to specific carbohydrate recognizing T cells through a unique mechanism. Here we review the key interactions between carbohydrate antigens and the adaptive immune system at the molecular, cellular and systems levels exploring the significant biological implications in health and disease.
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影响因子：
14.8
作者：
通讯作者：
--
DOI：
10.1038/newbio245012a0
发表时间：
1973-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
COUTINHO, A;MOLLER, G
通讯作者：
MOLLER, G
影响因子：
64.5
作者：
Cobb, BA;Wang, O;Kasper, DL
通讯作者：
Kasper, DL
影响因子：
3
作者：
Gad, M;Werdelin, O;Jensen, T
通讯作者：
Jensen, T
影响因子：
15.3
作者：
Brossay, L;Chioda, M;Burdin, N;Koezuka, Y;Casorati, G;Dellabona, P;Kronenberg, M
通讯作者：
Kronenberg, M