Biomolecular markers in cancer of the tongue.
Biomolecular markers in cancer of the tongue.
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DOI：
10.1155/2009/412908
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发表时间：
2009
影响因子：
--
通讯作者：
Foa P
中科院分区：
文献类型：
--
作者：
Ferrari D;Codecà C;Fiore J;Moneghini L;Bosari S;Foa P
舌癌的发病率在全球范围内不断增加，无论治疗如何，其侵袭性仍然很高。在头颈癌的病例中，经常报告基因变化和异常蛋白质的表达，但关于舌肿瘤的已发表的信息很少，这往往是矛盾的。本综述将集中于生物分子标记物的免疫组化表达及其与临床行为和预后的关系。这些蛋白质中的大多数与淋巴结分期、肿瘤进展和转移有关，但关于它们对无病生存期和总生存期以及治疗反应的影响仍存在争议。需要进行更广泛的临床研究，以确定分子改变的模式和最可靠的预测因子，以便根据缺氧标志物、血管和淋巴管生成因子、表皮生长因子受体、胞浆内信号传导和细胞凋亡的靶向，制定量身定制的抗肿瘤策略。
The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.
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影响因子：
6.4
作者：
Annertz, K;Anderson, H;Wennerberg, J
通讯作者：
Wennerberg, J
影响因子：
--
作者：
Bergamo, NA;Rogatto, SR;Squire, JA
通讯作者：
Squire, JA
影响因子：
45.3
作者：
Cohen, EEW;Rosen, F;Vokes, EE
通讯作者：
Vokes, EE
影响因子：
3.3
作者：
Bello, Ibrahim O.;Vilen, Suvi-Tuuli;Salo, Tuula
通讯作者：
Salo, Tuula
影响因子：
3
作者：
BYERS, RM
通讯作者：
BYERS, RM