Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period.
Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period.
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DOI：
10.1016/j.yebeh.2013.07.018
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Koh S
中科院分区：
文献类型：
--
作者：
Mlsna LM;Koh S
长期的早期癫痫发作与情感和认知功能的破坏有关。发作后紊乱，即癫痫发作后持续数小时至数天的暂时性功能缺陷，尚未得到彻底的表征。在这里，我们使用海人酸（KA）诱导癫痫持续状态（SE）在未成熟的大鼠在三个发展阶段（出生后第15，21，或30天），随后评估空间学习和记忆的巴恩斯迷宫，探索行为在一个开放的领域和时空分布的细胞损伤在第一个7-10天的poststictal期间。在SE后1天，P15-SE大鼠在巴恩斯迷宫中没有表现出缺陷，但与其同窝对照组相比，在开放视野中表现出过度探索。相反，P21-和P30-SE大鼠在巴恩斯迷宫上表现出明显受损的表现，并表现出明显减少的开放领域探索，暗示焦虑样行为。这些行为变化在P15大鼠中是短暂的，但在P21大鼠中更持久，并且在P30大鼠中是持久的。P21和P30大鼠行为缺陷的时间过程与外侧隔核、杏仁核和腹侧下托/CA 1中神经元损伤的存在时间相关，这些区域参与下丘脑-垂体-肾上腺应激反应的调节。
Prolonged early life seizures are associated with disruptions of affective and cognitive function. Postictal disturbances, temporary functional deficits that persist for hours to days after seizures, have not yet been thoroughly characterized. Here, we used kainic acid (KA) to induce status epilepticus (SE) in immature rats at three developmental stages (postnatal day 15, 21, or 30) and subsequently assessed spatial learning and memory in a Barnes Maze, exploratory behavior in an open field and the spatiotemporal distribution of cell injury during the first 7-10 days of the postictal period. At 1 day post-SE, P15-SE rats showed no deficit on a Barnes mazes, but were hyperexploratory in an open field compared to their littermate controls. In contrast, P21- and P30-SE rats exhibited markedly impaired performance on a Barnes Maze and exhibited significantly reduced open field exploration suggestive of anxiety-like behavior. These behavioral changes were transient in P15 rats but more persistent in P21 and enduring in P30 rats after KA-SE. The time course of behavioral deficits in P21 and P30 rats was temporally correlated with the presence of neuronal injury in the lateral septal nuclei, amygdala, and ventral subiculum/CA1, regions involved in modulation of the hypothalamic-pituitary-adrenal stress response.
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影响因子：
2.6
作者：
Alaverdashvili, M;Kubová, H;Mares, P
通讯作者：
Mares, P
影响因子：
2.6
作者：
Cardoso, Armando;Carvalho, Liliana S.;Lukoyanov, Nikolai V.
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Lukoyanov, Nikolai V.
影响因子：
5.6
作者：
Coulter, DA
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Coulter, DA
影响因子：
64.5
作者：
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通讯作者：
MAYFORD, M
影响因子：
5.3
作者：
Avignone, Elena;Ulmann, Lauriane;Audinat, Etienne
通讯作者：
Audinat, Etienne