Progression of Metastasis through Lymphatic System.
Progression of Metastasis through Lymphatic System.
复制标题
通过淋巴系统的转移进展
DOI:
10.3390/cells10030627
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发表时间:
2021-03-12
期刊:
影响因子:
6
通讯作者:
Padera TP
中科院分区:
文献类型:
--
作者:
Zhou H;Lei PJ;Padera TP
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits. In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.
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