Progression of Metastasis through Lymphatic System.

Progression of Metastasis through Lymphatic System.
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通过淋巴系统的转移进展

DOI:
10.3390/cells10030627
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发表时间:
2021-03-12
期刊:
影响因子:
6
通讯作者:
Padera TP
Padera TP
中科院分区:
生物学2区
文献类型:
--
作者:
Zhou H;Lei PJ;Padera TP

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淋巴转移是癌症患者最常见的转移部位。淋巴结疾病状况提供了很大的预后力量,但如何治疗淋巴转移仍在争论中。因此,重要的是要了解淋巴转移进展的机制,以及如何针对它们提供治疗益处。在这篇综述中,我们重点描述了癌细胞向淋巴管迁移和通过淋巴管迁移、在引流的淋巴结中存活以及进一步扩散到其他远处器官的过程。此外,还讨论了新出现的分子靶点和潜在的抑制淋巴结转移的策略。
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits. In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.
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