Potential impact of invasive surgical procedures on primary tumor growth and metastasis.
Potential impact of invasive surgical procedures on primary tumor growth and metastasis.
复制标题
侵入性手术程序对原发性肿瘤生长和转移的潜在影响。
DOI：
10.1007/s10585-018-9896-8
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发表时间：
2018-04
影响因子：
4
通讯作者：
Broekman MLD
中科院分区：
文献类型：
--
作者：
Alieva M;van Rheenen J;Broekman MLD
肿瘤切除和活检等外科手术仍然是实体瘤诊断和治疗的金标准，对患者有很大的益处。然而，越来越多的证据表明，即使是轻微的手术创伤也会影响几个（病理）生理过程，这些过程可能会促进术后转移扩散和肿瘤复发。局部效应包括肿瘤种植和伤口愈合反应，其可促进肿瘤细胞迁移、增殖、分化、细胞外基质重塑、血管生成和外渗。此外，局部和全身免疫抑制损害抗肿瘤免疫并有助于肿瘤细胞存活。肿瘤的手术操作可导致癌细胞释放到循环中，从而增加肿瘤细胞扩散的机会。为了防止手术干预的这些不期望的影响，已经提出了靶向免疫应答恶化或改变的治疗策略。本文综述了目前关于手术干预对肿瘤进展和扩散的局部、全身和继发部位影响的文献，并讨论了旨在确定潜在治疗方法以预防这些影响的研究，以进一步增加手术的临床获益。
Surgical procedures such as tumor resection and biopsy are still the gold standard for diagnosis and (determination of) treatment of solid tumors, and are prognostically beneficial for patients. However, growing evidence suggests that even a minor surgical trauma can influence several (patho) physiological processes that might promote postoperative metastatic spread and tumor recurrence. Local effects include tumor seeding and a wound healing response that can promote tumor cell migration, proliferation, differentiation, extracellular matrix remodeling, angiogenesis and extravasation. In addition, local and systemic immunosuppression impairs antitumor immunity and contributes to tumor cell survival. Surgical manipulation of the tumor can result in cancer cell release into the circulation, thus increasing the chance of tumor cell dissemination. To prevent these undesired effects of surgical interventions, therapeutic strategies targeting immune response exacerbation or alteration have been proposed. This review summarizes the current literature regarding these local, systemic and secondary site effects of surgical interventions on tumor progression and dissemination, and discusses studies that aimed to identify potential therapeutic approaches to prevent these effects in order to further increase the clinical benefit from surgical procedures.
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影响因子：
3.2
作者：
Cata JP;Velasquez JF;Ramirez MF;Vauthey JN;Gottumukkala V;Conrad C;Kim BJ;Aloia T
通讯作者：
Aloia T
影响因子：
3.8
作者：
Chen X;Zhu S;Fei X;Garfield DH;Wu J;Huang O;Li Y;Zhu L;He J;Chen W;Jin X;Shen K
通讯作者：
Shen K
影响因子：
4.6
作者：
Alieva, Maria;Margarido, Andreia S.;van Rheenen, Jacco
通讯作者：
van Rheenen, Jacco
影响因子：
51.1
作者：
Bockhorn, Maximilian;Jain, Rakesh K.;Munn, Lance L.
通讯作者：
Munn, Lance L.
影响因子：
8.8
作者：
Abramovitch, R;Marikovsky, M;Neeman, M
通讯作者：
Neeman, M