Identifying molecular drivers of gastric cancer through next-generation sequencing.
Identifying molecular drivers of gastric cancer through next-generation sequencing.
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DOI:
10.1016/j.canlet.2012.11.029
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发表时间:
2013-11-01
期刊:
影响因子:
9.7
通讯作者:
Kim, Yon Hui
中科院分区:
文献类型:
--
作者:
Liang, Han;Kim, Yon Hui
关键词:
Gastric cancer is the second most common cause of cancer-related death in the world, representing a major global health issue. The high mortality rate is largely due to the lack of effective medical treatment for advanced stages of this disease. Recently next-generation sequencing (NGS) technology has become a revolutionary tool for cancer research, and several NGS studies in gastric cancer have been published. Here we review the insights gained from these studies regarding how use NGS to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets. We also discuss the challenges and future directions of such efforts.
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