Identifying molecular drivers of gastric cancer through next-generation sequencing.

Identifying molecular drivers of gastric cancer through next-generation sequencing.
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DOI:
10.1016/j.canlet.2012.11.029
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发表时间:
2013-11-01
期刊:
影响因子:
9.7
通讯作者:
Kim, Yon Hui
Kim, Yon Hui
中科院分区:
医学1区
文献类型:
--
作者:
Liang, Han;Kim, Yon Hui

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胃癌是世界上癌症相关死亡的第二大常见原因,代表了一个主要的全球健康问题。死亡率高的主要原因是对这种疾病的晚期缺乏有效的治疗。近年来,下一代测序技术(NGS)已成为癌症研究的革命性工具,并已发表了几项胃癌NGS研究。在这里,我们回顾了从这些研究中获得的关于如何使用NGS阐明胃癌的分子基础和确定潜在的治疗靶点的见解。我们还讨论了这些努力的挑战和未来方向。
Gastric cancer is the second most common cause of cancer-related death in the world, representing a major global health issue. The high mortality rate is largely due to the lack of effective medical treatment for advanced stages of this disease. Recently next-generation sequencing (NGS) technology has become a revolutionary tool for cancer research, and several NGS studies in gastric cancer have been published. Here we review the insights gained from these studies regarding how use NGS to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets. We also discuss the challenges and future directions of such efforts.
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