Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb.

Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb.
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DOI:
10.1038/nn.2319
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发表时间:
2009-06
影响因子:
25
通讯作者:
Strowbridge, Ben W.
Strowbridge, Ben W.
中科院分区:
医学1区
文献类型:
--
作者:
Gao, Yuan;Strowbridge, Ben W.

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Using 2-photon-guided focal stimulation, we demonstrate spike timing-dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originate, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell EPSPs, and mitral cell inhibition, also were potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a novel mechanism to encode information by modulating bulbar inhibition.
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