Neurogliaform cells dynamically decouple neuronal synchrony between brain areas
Neurogliaform cells dynamically decouple neuronal synchrony between brain areas
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神经胶质细胞动态解耦大脑区域之间的神经元同步
DOI：
10.1126/science.abo3355
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发表时间：
2022
期刊：
影响因子：
56.9
通讯作者：
B. Lasztóczi
中科院分区：
文献类型：
--
作者：
Ece Sakalar;T. Klausberger;B. Lasztóczi
跨大脑区域的有效通信需要分布式神经元网络动态同步或解耦它们正在进行的活动。gaba能中间神经元锁定网络振荡的集合，但关于如何主动脱离同步以允许新的通信伙伴仍然存在问题。我们记录了清醒小鼠CA1海马区识别的中间神经元的活动。神经胶质细胞（ngfc）对锥体细胞的远端树突提供gaba能抑制，它们的放电与与皮质输入同步的局部网络的伽马振荡强烈耦合。ngfc的动作电位非但没有加强这种同步，反而使锥体细胞的活动与皮质伽马振荡脱钩，但没有减少锥体细胞的放电，也没有影响局部振荡。因此，ngfc通过暂时脱离同步来调节信息传输，而不会减少通信网络的活动。为了产生适应性行为，我们的大脑不断地组合来自多个来源的信息。面对不断的变化，神经元回路如何协调和维持不同输入流的平衡？Sakalar等人发现，神经胶质样细胞与与控制海马体和皮层相互作用相关的伽马振荡紧密耦合（参见Craig和Witton的观点）。神经胶质细胞的活动与锥体细胞放电和伽马振荡之间耦合的减少相关，而不影响锥体细胞的整体活动水平。神经胶质样细胞局部释放神经递质γ-氨基丁酸，在局部场电位的特定阶段选择性地降低新皮质输入对海马区CA1的影响。这种输入调制允许在不同时间传输不同类型的信息。脑神经元网络的输入选择涉及一个局部抑制细胞，它可以选择性地和暂时地解耦神经元同步。
Effective communication across brain areas requires distributed neuronal networks to dynamically synchronize or decouple their ongoing activity. GABAergic interneurons lock ensembles to network oscillations, but there remain questions regarding how synchrony is actively disengaged to allow for new communication partners. We recorded the activity of identified interneurons in the CA1 hippocampus of awake mice. Neurogliaform cells (NGFCs)—which provide GABAergic inhibition to distal dendrites of pyramidal cells—strongly coupled their firing to those gamma oscillations synchronizing local networks with cortical inputs. Rather than strengthening such synchrony, action potentials of NGFCs decoupled pyramidal cell activity from cortical gamma oscillations but did not reduce their firing nor affect local oscillations. Thus, NGFCs regulate information transfer by temporarily disengaging the synchrony without decreasing the activity of communicating networks. Description Fine-tuning information transfer To generate adaptive behavior, our brains constantly combine information from multiple sources. How do neuronal circuits orchestrate and maintain the balance of different input streams in the face of constant change? Sakalar et al. discovered that neurogliaform cells were strongly coupled with gamma oscillations that are associated with gating the interaction of hippocampus and cortex (see the Perspective by Craig and Witton). The activity of neurogliaform cells was correlated with a decrease in coupling between pyramidal cell firing and gamma oscillations without affecting the overall levels of activity of the pyramidal cells. Neurogliaform cells locally released the neurotransmitter γ-aminobutyric acid, which selectively decreased the influence of neocortical inputs to hippocampal area CA1 at specific stages in the local field potential. This modulation of inputs allows for the transfer of different types of information at different times. —PRS Input selection in brain neuronal networks involves a local inhibitory cell that can decouple neuronal synchrony selectively and temporarily.
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DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS
DOI：
10.1073/pnas.87.2.682
发表时间：
1990-01-01
影响因子：
11.1
作者：
BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
25
作者：
Palmigiano, Agostina;Geisel, Theo;Battaglia, Demian
通讯作者：
Battaglia, Demian
影响因子：
25
作者：
Schlesiger MI;Cannova CC;Boublil BL;Hales JB;Mankin EA;Brandon MP;Leutgeb JK;Leibold C;Leutgeb S
通讯作者：
Leutgeb S