The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients.
The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients.
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DOI：
10.1039/d1sc03597e
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发表时间：
2021-10-20
期刊：
影响因子：
8.4
通讯作者：
Hiscock JR
中科院分区：
文献类型：
--
作者：
Hilton KLF;Manwani C;Boles JE;White LJ;Ozturk S;Garrett MD;Hiscock JR
虽然癌症现在比以往任何时候都更多地影响着人类的健康和福祉，但抗菌素耐药性细菌感染的指数增长意味着抗菌素耐药性预计将成为未来对人类健康的最大威胁之一。因此，开发可用于治疗癌症和抗菌素耐药性感染的新型治疗策略至关重要。无论治疗剂的靶点是在细胞内还是在细胞膜内，它都必须与磷脂屏障相互作用或穿过磷脂屏障，以引起所需的细胞效应。在这里，我们总结了已发表的关于细菌和癌细胞系的磷脂膜组成以及癌症患者的生物样本的研究结果。这些数据不仅突出了这些生物样品的膜组成的关键差异，而且还说明了用于阐明和报告微生物和癌症领域之间类似研究结果的方法。本文综述了从微生物和癌症领域收集的细胞膜磷脂组成数据的存储和比较。
While cancer now impacts the health and well-being of more of the human population than ever before, the exponential rise in antimicrobial resistant (AMR) bacterial infections means AMR is predicted to become one of the greatest future threats to human health. It is therefore vital that novel therapeutic strategies are developed that can be used in the treatment of both cancer and AMR infections. Whether the target of a therapeutic agent be inside the cell or in the cell membrane, it must either interact with or cross this phospholipid barrier to elicit the desired cellular effect. Here we summarise findings from published research into the phospholipid membrane composition of bacterial and cancer cell lines and biological samples from cancer patients. These data not only highlight key differences in the membrane composition of these biological samples, but also the methods used to elucidate and report the results of this analogous research between the microbial and cancer fields. This review acts as a repository and comparison of cell membrane phospholipid composition data collected from microbial and cancer fields.
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影响因子：
3.9
作者：
Boles JE;Ellaby RJ;Shepherd HJ;Hiscock JR
通讯作者：
Hiscock JR
影响因子：
3.9
作者：
Dora NO;Blackburn E;Boles JE;Williams GT;White LJ;Turner SEG;Hothersall JD;Askwith T;Doolan JA;Mulvihill DP;Garrett MD;Hiscock JR
通讯作者：
Hiscock JR
影响因子：
4.9
作者：
Chertok B;Webber MJ;Succi MD;Langer R
通讯作者：
Langer R
影响因子：
78.8
作者：
Cleeland, Charles S.;Allen, Jeff D.;Skillings, Jamey
通讯作者：
Skillings, Jamey
影响因子：
4.1
作者：
Bernat P;Paraszkiewicz K;Siewiera P;Moryl M;Płaza G;Chojniak J
通讯作者：
Chojniak J