Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.
Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.
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DOI：
10.1021/mp4003283
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发表时间：
2013-10-07
影响因子：
4.9
通讯作者：
Langer R
中科院分区：
文献类型：
--
作者：
Chertok B;Webber MJ;Succi MD;Langer R
早期的科幻小说将未来的药物输送设想为有针对性的微米级潜艇和“机器人”身体部位。在这里，我们描述了该领域的技术进展，这些技术现在开始捕捉这一早期愿景的各个方面。具体来说，我们关注药物输送中两种最突出的系统类型——用于输送到病理部位的血管内微/纳米药物载体和促进以预定动力学释放或响应特定提示的载药植入装置。我们讨论了激发这些设计灵感的未满足的临床需求、对其实现构成困难挑战的生理因素，以及有望提供可靠解决方案的可行技术。我们还根据材料工程的预期进展和未来诊断的背景，对未来 50 年药物输送的发展前景提出了展望。
Early science fiction envisioned the future of drug delivery as targeted micron-scale submarines and ‘Cyborg’ body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery – the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the pre-defined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics.
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影响因子：
3.8
作者：
Brown, LR;Edelman, ER;Langer, R
通讯作者：
Langer, R
影响因子：
16.1
作者：
Aggarwal P;Hall JB;McLeland CB;Dobrovolskaia MA;McNeil SE
通讯作者：
McNeil SE
影响因子：
10
作者：
Bratlie, Kaitlin M.;York, Roger L.;Invernale, Michael A.;Langer, Robert;Anderson, Daniel G.
通讯作者：
Anderson, Daniel G.
影响因子：
1.4
作者：
Casadio M;Ranganathan R;Mussa-Ivaldi FA
通讯作者：
Mussa-Ivaldi FA
影响因子：
--
作者：
BELLISLE, F;LOUISSYLVESTRE, J;LEMAGNEN, J
通讯作者：
LEMAGNEN, J