Immune-Microbiota Crosstalk Underlying Inflammatory Bowel Disease
Immune-Microbiota Crosstalk Underlying Inflammatory Bowel Disease
复制标题
炎症性肠病背后的免疫微生物群串扰
DOI：
10.1007/978-3-030-91415-8_2
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Qiu, Peng
中科院分区：
文献类型：
--
作者：
Xu, Congmin;Mac, Quoc D.;Jia, Qiong;Qiu, Peng
长期的进化已经形成了由肠道微生物群与宿主免疫系统组成的和谐的宿主-微生物群共生关系。炎症性肠道疾病（IBD）是生态失调的微生物组成以及异常的粘膜免疫反应的结果，而其潜在机制尚不清楚。在这份报告中，我们创造性地提出，当与宿主代谢相关时，功能性微生物群落比单个细菌更重要。基于这一假设，我们进行了系统分析，以表征在一组新诊断的克罗恩病（CD）样本和健康对照中建立的宿主和肠道微生物群的共代谢。从宿主方面，我们应用基因集富集分析宿主粘膜蛋白质组数据，以确定与CD相关的宿主途径。与此同时，我们对粘膜微生物群的宏基因组数据进行了群落检测分析，以识别那些为功能目的而组装的微生物群落。并对寄主途径与微生物群落进行了相关性分析。我们发现两个微生物群落与IBD富集宿主途径呈负相关。这两种微生物群落的优势属被称为健康益处，可以作为设计用于IBD治疗的复杂有益微生物的参考。相关的宿主途径都与MHC抗原呈递途径相关，这暗示了IBD潜在的免疫-微生物群串扰的可能机制。
Long-time evolution has shaped a harmonious host-microbiota symbiosis consisting of intestinal microbiota in conjunction with the host immune system. Inflammatory bowel disease (IBD) is a result of the dysbiotic microbial composition together with aberrant mucosal immune responses, while the underlying mechanism is far from clear. In this report, we creatively proposed that when correlating with the host metabolism, functional microbial communities matter more than individual bacteria. Based on this assumption, we performed a systematic analysis to characterize the co-metabolism of host and gut microbiota established on a set of newly diagnosed Crohn’s disease (CD) samples and healthy controls. From the host side, we applied gene set enrichment analysis on host mucosal proteome data to identify those host pathways associated with CD. At the same time, we applied community detection analysis on the metagenomic data of mucosal microbiota to identify those microbial communities, which were assembled for a functional purpose. Then, the correlation analysis between host pathways and microbial communities was conducted. We discovered two microbial communities negatively correlated with IBD enriched host pathways. The dominant genera for these two microbial communities are known as health-benefits and could serve as a reference for designing complex beneficial microorganisms for IBD treatment. The correlated host pathways are all relevant to MHC antigen presentation pathways, which hints toward a possible mechanism of immune-microbiota cross talk underlying IBD.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
Epstein-Barr 病毒对 CR2 转染的上皮细胞的感染揭示了病毒颗粒上存在 MHC II 类。
影响因子：
3.7
作者：
P. Knox;Lawrence S. Young
通讯作者：
Lawrence S. Young
影响因子：
5.2
作者：
Ple, Coline;Breton, Jerome;Foligne, Benoit
通讯作者：
Foligne, Benoit
影响因子：
30.3
作者：
Gevers D;Kugathasan S;Denson LA;Vázquez-Baeza Y;Van Treuren W;Ren B;Schwager E;Knights D;Song SJ;Yassour M;Morgan XC;Kostic AD;Luo C;González A;McDonald D;Haberman Y;Walters T;Baker S;Rosh J;Stephens M;Heyman M;Markowitz J;Baldassano R;Griffiths A;Sylvester F;Mack D;Kim S;Crandall W;Hyams J;Huttenhower C;Knight R;Xavier RJ
通讯作者：
Xavier RJ
影响因子：
3.7
作者：
Miyake S;Kim S;Suda W;Oshima K;Nakamura M;Matsuoka T;Chihara N;Tomita A;Sato W;Kim SW;Morita H;Hattori M;Yamamura T
通讯作者：
Yamamura T