Effects of lithium on oxidative stress parameters in healthy subjects.
Effects of lithium on oxidative stress parameters in healthy subjects.
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DOI：
10.3892/mmr.2011.732
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发表时间：
2012-03
影响因子：
3.4
通讯作者：
Machado-Vieira R
中科院分区：
文献类型：
--
作者：
Khairova R;Pawar R;Salvadore G;Juruena MF;de Sousa RT;Soeiro-de-Souza MG;Salvador M;Zarate CA;Gattaz WF;Machado-Vieira R
增加的神经元氧化应激（OxS）主要通过诱导膜、蛋白质和基因中的脂质过氧化而对信号转导、结构可塑性和细胞弹性产生有害影响。OxS水平的主要标志物包括硫代巴比妥酸反应物质（TBARS）和酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶。锂已被证明可以预防和/或逆转DNA损伤，自由基形成和脂质过氧化在不同的模型。本研究评估了锂治疗前后健康志愿者的OxS参数。健康志愿者接受治疗剂量的锂治疗2-4周。在健康志愿者中使用锂治疗选择性地改变了所有受试者的SOD水平。此外，在锂处理后观察到SOD/CAT比率的显著降低，这与通过降低过氧化氢水平来降低OxS相关。SOD/CAT比值的降低可能导致OxS降低，主要表现为细胞过氧化氢浓度的降低。总体而言，目前的研究结果表明，锂在健康受试者中的抗氧化作用具有潜在作用，支持其在双相情感障碍（BD）和神经退行性过程中的神经保护作用。
Increased neuronal oxidative stress (OxS) induces deleterious effects on signal transduction, structural plasticity and cellular resilience, mainly by inducing lipid peroxidation in membranes, proteins and genes. Major markers of OxS levels include the thiobarbituric acid reactive substances (TBARS) and the enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase. Lithium has been shown to prevent and/or reverse DNA damage, free-radical formation and lipid peroxidation in diverse models. This study evaluates OxS parameters in healthy volunteers prior to and following lithium treatment. Healthy volunteers were treated with lithium in therapeutic doses for 2–4 weeks. Treatment with lithium in healthy volunteers selectively altered SOD levels in all subjects. Furthermore, a significant decrease in the SOD/CAT ratio was observed following lithium treatment, wich was associated with decreased OxS by lowering hydrogen peroxide levels. This reduction in the SOD/CAT ratio may lead to lower OxS, indicated primarily by a decrease in the concentration of cell hydrogen peroxide. Overall, the present findings indicate a potential role for the antioxidant effects of lithium in healthy subjects, supporting its neuroprotective profile in bipolar disorder (BD) and, possibly, in neurodegenerative processes.
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影响因子：
2.9
作者：
Schäfer, M;Goodenough, S;Behl, C
通讯作者：
Behl, C
DOI：
10.1046/j.1525-1373.1999.d01-140.x
发表时间：
1999-12-01
影响因子：
--
作者：
Floyd, RA
通讯作者：
Floyd, RA
影响因子：
4.8
作者：
Andreazza, Ana Cristina;Cassini, Carina;Goncalves, Carlos Alberto
通讯作者：
Goncalves, Carlos Alberto
影响因子：
4.1
作者：
WILLS, ED
通讯作者：
WILLS, ED
DOI：
10.4088/jcp.v69n0806
发表时间：
2008-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Machado-Vieira R;Soares JC;Lara DR;Luckenbaugh DA;Busnello JV;Marca G;Cunha A;Souza DO;Zarate CA Jr;Kapczinski F
通讯作者：
Kapczinski F