Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder.
Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder.
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DOI：
10.1002/brb3.2125
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发表时间：
2021-05
影响因子：
3.1
通讯作者：
Qiu W
中科院分区：
文献类型：
--
作者：
Liu C;Xiao H;Zhang X;Zhao Y;Li R;Zhong X;Wang Y;Shu Y;Chang Y;Wang J;Li C;Lin H;Qiu W
The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Patients with MS (n = 83) and AQP4‐IgG‐seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell‐inner plexiform layer (GC‐IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve. Compared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC‐IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p < .001; 68.0 [56.0; 81.0] μm, versus 74.5 [64.2; 81.0] μm, p < .001) and significantly smaller whole VD and PD areas (15.6 [12.6; 17.0] mm−1 versus 16.7 [14.8; 17.7] mm−1, p < .001; 0.38 [0.31; 0.42] mm−1 versus 0.40 [0.37; 0.43] mm−1, p < .01). The combination of structural parameters (average thickness of the pRNFL and GC‐IPL) with microvascular parameters (temporal‐inner quadrant of VD, temporal‐inner, nasal‐inferior, and nasal‐outer quadrant of PD) was revealed to have a good diagnostic capability for discriminating between NMOSD and MS. OCT angiography reveals different structural and microvascular retinal changes in MS and AQP4‐IgG‐seropositive NMOSD. These combined structural and microvascular parameters might be promising biomarkers for disease diagnosis. In summary, our study compared the structure and flow between patients with MS and those with AQP4‐IgG‐positive NMOSD, indicating pathophysiological differences between them and suggesting that OCTA may have an additive effect as a biomarker in conjunction with routine OCT measurements. Combining OCTA and OCT may yield promising diagnostic properties in distinguishing both diseases.
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DOI：
10.1093/brain/awq133
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Calabresi PA;Balcer LJ;Frohman EM
通讯作者：
Frohman EM
影响因子：
5.8
作者：
Murphy, Olwen C.;Kwakyi, Ohemaa;Saidha, Shiv
通讯作者：
Saidha, Shiv
DOI：
10.1177/1352458514567216
发表时间：
2015-05
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Bennett JL;de Seze J;Lana-Peixoto M;Palace J;Waldman A;Schippling S;Tenembaum S;Banwell B;Greenberg B;Levy M;Fujihara K;Chan KH;Kim HJ;Asgari N;Sato DK;Saiz A;Wuerfel J;Zimmermann H;Green A;Villoslada P;Paul F;GJCF-ICC&BR
通讯作者：
GJCF-ICC&BR
影响因子：
5.8
作者：
Ayrignac, Xavier;Daliere, Clarisse Carra;Labauge, Pierre
通讯作者：
Labauge, Pierre
影响因子：
13.7
作者：
Fernandes DB;Raza AS;Nogueira RG;Wang D;Callegaro D;Hood DC;Monteiro ML
通讯作者：
Monteiro ML