Marginal zinc deficiency in older adults: responsiveness of zinc status indicators.
Marginal zinc deficiency in older adults: responsiveness of zinc status indicators.
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老年人的边缘锌缺乏：锌状态指标的反应性。
DOI：
10.1080/07315724.1994.10718434
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发表时间：
1994
影响因子：
3.5
通讯作者：
Lin,PH
中科院分区：
文献类型：
--
作者：
Bales,CW;DiSilvestro,RA;Currie,KL;Plaisted,CS;Joung,H;Galanos,AN;Lin,PH
怀疑轻度缺锌是常见的老年人不能证实或反驳，因为缺乏明确的指标锌状态。本研究的目的是记录一组饮食严格控制的老年人锌状态参数的临床反应：第一个中等偏低的锌（3.97毫克/天，持续15天），然后高锌（28.19毫克/天，持续6天）。（平均年龄= 66.6岁）自愿食用轻微缺锌的饮食15天，随后6天补锌。在缺锌和补锌前后测定红细胞金属硫蛋白和5′-核苷酸酶的血浆浓度，以及锌、碱性磷酸酶、铜和铜蓝蛋白的水平。碱性磷酸酶（AP）值并没有改变预期的方向，虽然在AP的一个小的减少后，锌补充有统计学意义。红细胞金属硫蛋白结果遵循类似于碱性磷酸酶的模式，几乎没有变化，但在锌补充后有小的统计学显著性下降。正如预期的那样，血浆铜和铜蓝蛋白水平没有饮食相关的变化。相反，在缺锌期间，血浆中5′-核苷酸酶的浓度从2.7 +/-0.5 U降至1.1 +/-0.5 U（p < 0.01），而在6天的饱足后，5 ′-核苷酸酶的浓度又升高（p < 0.05）至2.2 +/-0.4 U（p < 0.05）。在这项研究中，传统的指标，如血浆锌和碱性磷酸酶没有改变，因为将预期在锌摄入量的变化。同样，红细胞金属硫蛋白对锌摄入量的改变没有反应，但这一因素可能反映了长期或更严重的锌缺乏，因此需要进一步研究。酶5′-核苷酸酶的活性似乎对锌摄入量的急性变化有反应;然而，需要更多的工作来确定这些活性如何反映其他类型受试者的锌摄入量。
Suspicions that mild zinc deficiency is common among the elderly cannot be confirmed or refuted because definitive indicators of zinc status are lacking. The goal of this study was to document the clinical responsiveness of parameters of zinc status in a group of older adults consuming a carefully controlled diet: first moderately low in zinc (3.97 mg/day for 15 days) and then high in zinc (28.19 mg/day for 6 days).Fifteen older adults (mean age = 66.6 yrs) volunteered to consume a marginally zinc-deficient diet for 15 days followed by 6 days of zinc repletion. Plasma concentrations of erythrocyte metallothionein and the enzyme 5′-nucleotidase, as well as levels of zinc, alkaline phosphatase, copper and ceruloplasmin were measured before and after zinc depletion and repletion.Plasma zinc levels were not altered during the study. Alkaline phosphatase (AP) values did not change in the expected direction, although a small decrease in AP following zinc repletion was statistically significant. Erythrocyte metallothionein results followed a pattern similar to that of alkaline phosphatase, little change, but a small, statistically significant drop after zinc repletion. As expected, there were no diet-associated changes in plasma copper and ceruloplasmin levels. In contrast, plasma concentrations of the enzyme 5′-nucleotidase decreased (p < 0.01) from 2.7 +/− 0.5 to 1.1 +/− 0.5 U during zinc depletion and increased (p < 0.05) to 2.2 +/− 0.4 U after 6 days of repletion.Mild zinc deficiency is difficult to detect. In this study, traditional indicators such as plasma zinc and alkaline phosphatase did not change as would be expected in response to alterations in zinc intake. Likewise, erythrocyte metallothionein did not respond to altered zinc intakes as expected but this factor may reflect long-standing or more severe zinc depletion and thus requires additional study. Activity of the enzyme 5′-nucleotidase appears responsive to acute changes in zinc intake; however, more work is needed to define how well these activities will reflect zinc intake in other types of subjects.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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