The Role of Nucleotide Excision Repair in Cisplatin-Induced Peripheral Neuropathy: Mechanism, Prevention, and Treatment.
The Role of Nucleotide Excision Repair in Cisplatin-Induced Peripheral Neuropathy: Mechanism, Prevention, and Treatment.
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DOI：
10.3390/ijms22041975
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发表时间：
2021-02-17
影响因子：
5.6
通讯作者：
Xia F
中科院分区：
文献类型：
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作者：
Acklin S;Xia F
铂类化疗引起的周围神经病变（CIPN）是癌症治疗中最常见的剂量限制效应之一，导致剂量减少和停止挽救生命的化疗。它的衰弱效应往往是永久性的，并导致癌症患者的生活质量终身受损。虽然毒性机制尚未完全确定，但背根神经节感觉神经元在症状发展中起着不可或缺的作用。dna -铂加合物在这些细胞中积累并抑制正常的细胞功能。核苷酸切除修复（NER）是铂加合物修复不可或缺的一部分，其机制涉及的蛋白质可作为未来治疗的潜在靶点。本综述旨在强调NER在顺铂诱导的周围神经病变中的作用，总结目前的临床毒性方法，并讨论未来预防和治疗CIPN的前景。
Platinum-based chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting effects of cancer treatment and results in dose reduction and discontinuation of life-saving chemotherapy. Its debilitating effects are often permanent and lead to lifelong impairment of quality of life in cancer patients. While the mechanisms underlying the toxicity are not yet fully defined, dorsal root ganglia sensory neurons play an integral role in symptom development. DNA-platinum adducts accumulate in these cells and inhibit normal cellular function. Nucleotide excision repair (NER) is integral to the repair of platinum adducts, and proteins involved in its mechanism serve as potential targets for future therapeutics. This review aims to highlight NER’s role in cisplatin-induced peripheral neuropathy, summarize current clinical approaches to the toxicity, and discuss future perspectives for the prevention and treatment of CIPN.
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影响因子：
8.8
作者：
Courneya, K. S.;McKenzie, D. C.;Mackey, J. R.;Gelmon, K.;Friedenreich, C. M.;Yasui, Y.;Reid, R. D.;Vallerand, J. R.;Adams, S. C.;Proulx, C.;Dolan, L. B.;Wooding, E.;Segal, R. J.
通讯作者：
Segal, R. J.
影响因子：
3.9
作者：
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通讯作者：
VANDERSANDE, JJ
影响因子：
5.6
作者：
Duan M;Ulibarri J;Liu KJ;Mao P
通讯作者：
Mao P
影响因子：
5.3
作者：
Dzagnidze, Anna;Katsarava, Zaza;Thomale, Juergen
通讯作者：
Thomale, Juergen
影响因子：
9
作者：
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