Macrophages under pressure: the role of macrophage polarization in hypertension.
Macrophages under pressure: the role of macrophage polarization in hypertension.
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DOI：
10.1016/j.trsl.2017.10.011
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Harwani SC
中科院分区：
文献类型：
--
作者：
Harwani SC
高血压是一种多因素疾病，涉及神经、肾脏和心血管系统。巨噬细胞是最丰富和普遍存在的免疫细胞，将它们置于独特的位置，作为这些组分之间的关键介质。巨噬细胞的极化赋予了巨大的表型和功能可塑性，使它们能够充当促炎剂、稳态剂和抗炎剂。M1和M2表型之间的关键差异，这两个子集在极端的极化谱，放置在一个交界处巨噬细胞介导的许多机制参与高血压的发病机制。免疫系统的神经元和非神经元调节，即“神经免疫”轴，在巨噬细胞的极化中起着不可或缺的作用。在高血压中，“神经-免疫”轴导致巨噬细胞从免疫细胞库的动员和它们的趋化性的同步化，通过增加趋化剂的表达，到达在高血压发展中至关重要的终末器官。这个复杂的系统在很大程度上是由巨噬细胞上胆碱能、肾上腺素能和神经激素受体的自主神经元和非神经元激活的二分作用协调的，导致它们在活性炎症部位的表型之间“切换”的能力。来自实验模型和人体研究的数据彼此一致，并支持巨噬细胞极化在高血压发病机制中的核心作用。
Hypertension is a multi-factorial disease, involving the nervous, renal, and cardiovascular systems. Macrophages are the most abundant and ubiquitous immune cells, placing them in a unique position to serve as key mediators between these components. The polarization of macrophages confers vast phenotypic and functional plasticity, allowing them to act as pro-inflammatory, homeostatic, and anti-inflammatory agents. Key differences between the M1 and M2 phenotypes, the two subsets at the extremes of this polarization spectrum, place macrophages at a juncture to mediate many mechanisms involved in the pathogenesis of hypertension. Neuronal and non-neuronal regulation of the immune system, i.e. the “neuro-immuno” axis, plays an integral role in the polarization of macrophages. In hypertension, the “neuro-immuno” axis results in synchronization of macrophage mobilization from immune cell reservoirs and their chemotaxis, via increased expression of chemoattractants, to end-organs critical in the development of hypertension. This complicated system is largely coordinated by the dichotomous actions of the autonomic neuronal and non-neuronal activation of cholinergic, adrenergic, and neurohormonal receptors on macrophages, leading to their ability to “switch” between phenotypes at sites of active inflammation. Data from experimental models and human studies are in concordance with each other and support a central role for macrophage polarization in the pathogenesis of hypertension.
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影响因子：
16.6
作者：
Carnevale, Daniela;Perrotta, Marialuisa;Pallante, Fabio;Fardella, Valentina;Iacobucci, Roberta;Fardella, Stefania;Carnevale, Lorenzo;Carnevale, Raimondo;De Lucia, Massimiliano;Cifelli, Giuseppe;Lembo, Giuseppe
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影响因子：
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作者：
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通讯作者：
Schiffrin, Ernesto L.
DOI：
10.1152/ajpheart.00247.2015
发表时间：
2016-02-01
影响因子：
4.8
作者：
Biancardi, Vinicia Campana;Stranahan, Alexis M.;Stern, Javier E.
通讯作者：
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影响因子：
20.3
作者：
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通讯作者：
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