A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.
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DOI：
10.1038/ncomms13035
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发表时间：
2016-09-27
影响因子：
16.6
通讯作者：
Lembo, Giuseppe
中科院分区：
文献类型：
--
作者：
Carnevale, Daniela;Perrotta, Marialuisa;Pallante, Fabio;Fardella, Valentina;Iacobucci, Roberta;Fardella, Stefania;Carnevale, Lorenzo;Carnevale, Raimondo;De Lucia, Massimiliano;Cifelli, Giuseppe;Lembo, Giuseppe
免疫系统在高血压中的关键作用现已得到广泛认可。我们之前报道过，高血压挑战将神经驱动与免疫系统激活结合起来，但这种联系的生理和分子机制尚不清楚。在这里，我们发现高血压挑战会激活脾交感神经放电以引发免疫反应。更具体地说，由烟碱胆碱能受体介导的迷走脾神经驱动连接大脑和脾脏。在腹腔迷走神经切断小鼠和缺乏α7nAChR（一种通常由外周神经节神经元表达的受体）的小鼠中，高血压刺激诱导的交感神经放电都不存在。这种胆碱能-交感神经通路对于高血压挑战时 T 细胞的激活和排出是必需的。此外，我们还发现，选择性热消融脾神经可以防止 T 细胞流出并预防高血压。这种选择性脾去神经术的新实验方法提出了治疗难治性高血压的新临床策略。 免疫系统参与高血压的发展。在这里，作者表明，由 α7nAChR 受体介导的胆碱能交感通路和脾 T 细胞的激活在高血压期间引发免疫，并且选择性脾去神经可以预防小鼠高血压的发作。
The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connection are unknown. Here, we show that hypertensive challenges activate splenic sympathetic nerve discharge to prime immune response. More specifically, a vagus-splenic nerve drive, mediated by nicotinic cholinergic receptors, links the brain and spleen. The sympathetic discharge induced by hypertensive stimuli was absent in both coeliac vagotomized mice and in mice lacking α7nAChR, a receptor typically expressed by peripheral ganglionic neurons. This cholinergic-sympathetic pathway is necessary for T cell activation and egression on hypertensive challenges. In addition, we show that selectively thermoablating the splenic nerve prevents T cell egression and protects against hypertension. This novel experimental procedure for selective splenic denervation suggests new clinical strategies for resistant hypertension. Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice.
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影响因子：
4.6
作者：
Deck, J;Bibevski, S;Dunlap, ME
通讯作者：
Dunlap, ME
影响因子：
15.1
作者：
Nance, Dwight M.;Sanders, Virginia M.
通讯作者：
Sanders, Virginia M.
影响因子：
20.1
作者：
GUO, GB;THAMES, MD;ABBOUD, FM
通讯作者：
ABBOUD, FM
影响因子：
20.1
作者：
McMaster WG;Kirabo A;Madhur MS;Harrison DG
通讯作者：
Harrison DG
DOI：
10.1084/jem.20120571
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Andersson U;Tracey KJ
通讯作者：
Tracey KJ