Effects of second hand smoke on airway secretion and mucociliary clearance.
Effects of second hand smoke on airway secretion and mucociliary clearance.
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DOI：
10.3389/fphys.2012.00342
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发表时间：
2012
影响因子：
4
通讯作者：
Di YP
中科院分区：
文献类型：
--
作者：
Liu Y;Di YP
呼吸道是抵御吸入的病原体和来自环境的颗粒物的第一道防线。呼吸道清除吸入异物的一种主要方式是通过粘膜纤毛清除（mucocile clearance， MCC），这是呼吸道先天免疫防御肺部疾病的重要组成部分。MCC的特征是粘液通过纤毛运动向上移动，这需要粘液的体积和成分、充足的纤毛周液体（PCL）体积和正常的纤毛搏动频率（CBF）之间的平衡。气道表面液（ASL）是一种薄层液体，由高粘性的黏液上“凝胶”层和含水润滑的下“溶胶”层组成。粘液的产生、分泌和清除被认为在维持气道健康中起着至关重要的作用，因为它维持气道中的水合作用，并捕获颗粒、细菌和病毒。不同类型的上皮细胞，包括分泌细胞和纤毛细胞，参与MCC的功能。香烟烟雾（CS）中含有的化学物质和微粒会显著影响气道分泌。主动和被动cs诱导的慢性阻塞性肺疾病（COPD）通常与杯状细胞和粘膜下腺（smg）的增生有关，从而增加气道的分泌能力，从而损害MCC。
The airway acts as the first defense against inhaled pathogens and particulate matter from the environment. One major way for the airway to clear inhaled foreign objects is through mucociliary clearance (MCC), an important component of the respiratory innate immune defense against lung disease. MCC is characterized by the upward movement of mucus by ciliary motion that requires a balance between the volume and composition of the mucus, adequate periciliary liquid (PCL) volume, and normal ciliary beat frequency (CBF). Airway surface fluid (ASL) is a thin layer liquid that consists of the highly viscous mucus upper “gel” layer, and the watery lubricating lower “sol” layer. Mucus production, secretion and clearance are considered to play a critical role in maintenance of airway health because it maintains hydration in the airway and traps particulates, bacteria, and viruses. Different types of epithelial cells, including secretory cells, and ciliated cells, contribute to the MCC function. Cigarette smoke (CS) contains chemicals and particulates that significantly affect airway secretion. Active and passive CS-induced chronic obstructive pulmonary disease (COPD) is frequently associated with hyperplasia of goblet cells and submucosal glands (SMGs), thus increasing the secretory capacity of the airways that impairs MCC.
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影响因子：
105.7
作者：
Houston, TK;Person, SD;Kiefe, CI
通讯作者：
Kiefe, CI
影响因子：
3.1
作者：
Eisner, Mark D;Balmes, John;Blanc, Paul D
通讯作者：
Blanc, Paul D
DOI：
10.1165/ajrcmb.26.4.4473
发表时间：
2002-04-01
影响因子：
6.4
作者：
Fischer, BM;Voynow, JA
通讯作者：
Voynow, JA
DOI：
10.1164/ajrccm.157.6.9707011
发表时间：
1998-06-01
影响因子：
24.7
作者：
Boers, JE;Ambergen, AW;Thunnissen, FBJM
通讯作者：
Thunnissen, FBJM
影响因子：
--
作者：
Borgerding, M;Klus, H
通讯作者：
Klus, H