Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database.
Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database.
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DOI：
10.1007/s00246-021-02609-x
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发表时间：
2021-08
影响因子：
1.6
通讯作者：
Pediatric Heart Network Investigators
中科院分区：
文献类型：
--
作者：
Mahgerefteh J;Lai W;Colan S;Trachtenberg F;Gongwer R;Stylianou M;Bhat AH;Goldberg D;McCrindle B;Frommelt P;Sachdeva R;Shuplock JM;Spurney C;Troung D;Cnota JF;Camarda JA;Levine J;Pignatelli R;Altmann K;van der Velde M;Thankavel PP;Chowdhury S;Srivastava S;Johnson TR;Lopez L;Pediatric Heart Network Investigators
标准化的心血管测量的身体大小允许不同年龄的儿童之间的比较，并从正常的生理生长区分病理变化。由于越来越多的人对使用身高进行标准化感兴趣，本研究的目的是开发基于身高的标准化模型，并将其与基于体表面积（BSA）的主动脉和左心室（LV）测量标准化进行比较。研究人群包括参加儿科心脏网络回波Z评分项目的2至18岁的健康、非肥胖儿童。超声心动图研究参数包括3个位置的近端主动脉直径、LV舒张末期容积和LV质量。使用原始项目中描述的统计方法，确定研究参数的基于身高和BSA的Z评分，并检验与年龄、性别、人种、种族和体重指数（BMI）的任何临床显著关系。在研究人群中，体重不足、正常体重和超重（但不肥胖）儿童之间比较了基于身高与BSA的标准化模型。计算了5个研究参数基于身高和BSA的Z评分，结果显示与年龄、性别、人种和种族之间无临床显著关系。与超重组相比，基于身高的标准化导致体重不足组的Z评分较低，而基于BSA的标准化导致体重不足组的Z评分高于超重组。换句话说，与基于BSA的Z分数相比，增加BMI对基于身高的Z分数具有相反的影响。基于身高和BSA的主动脉和LV尺寸的异速生长归一化是可行的。然而，基于身高的正常化导致较重儿童的心血管Z分数较高，基于BSA的正常化导致较轻儿童的心血管Z分数较高。需要进一步的研究来评估这些方法在患有或不患有心脏病的肥胖儿童中的性能。
Normalizing cardiovascular measurements for body size allows for comparison among children of different ages and for distinguishing pathologic changes from normal physiologic growth. Because of growing interest to use height for normalization, the aim of this study was to develop height-based normalization models and compare them to body surface area (BSA)-based normalization for aortic and left ventricular (LV) measurements. The study population consisted of healthy, non-obese children between 2 and 18 years of age enrolled in the Pediatric Heart Network Echo Z-Score Project. The echocardiographic study parameters included proximal aortic diameters at 3 locations, LV end-diastolic volume, and LV mass. Using the statistical methodology described in the original project, Z-scores based on height and BSA were determined for the study parameters and tested for any clinically significant relationships with age, sex, race, ethnicity, and body mass index (BMI). Normalization models based on height versus BSA were compared among underweight, normal weight, and overweight (but not obese) children in the study population. Z-scores based on height and BSA were calculated for the 5 study parameters and revealed no clinically significant relationships with age, sex, race, and ethnicity. Normalization based on height resulted in lower Z-scores in the underweight group compared to the overweight group, whereas normalization based on BSA resulted in higher Z-scores in the underweight group compared to the overweight group. In other words, increasing BMI had an opposite effect on height-based Z-scores compared to BSA-based Z-scores. Allometric normalization based on height and BSA for aortic and LV sizes is feasible. However, height-based normalization results in higher cardiovascular Z-scores in heavier children, and BSA-based normalization results in higher cardiovascular Z-scores in lighter children. Further studies are needed to assess the performance of these approaches in obese children with or without cardiac disease.
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DOI：
10.1161/circimaging.113.000532
发表时间：
2013-09
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Neeland IJ;Gupta S;Ayers CR;Turer AT;Rame JE;Das SR;Berry JD;Khera A;McGuire DK;Vega GL;Grundy SM;de Lemos JA;Drazner MH
通讯作者：
Drazner MH
影响因子：
37.8
作者：
Foster, Bethany J.;Mackie, Andrew S.;Colan, Steven D.
通讯作者：
Colan, Steven D.
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
2.7
作者：
Cuspidi, C.;Meani, S.;Mancia, G.
通讯作者：
Mancia, G.
影响因子：
14
作者：
Armstrong, Anderson C.;Gidding, Samuel;Gjesdal, Ola;Wu, Colin;Bluemke, David A.;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.