A depauperate immune repertoire precedes evolution of sociality in bees.
A depauperate immune repertoire precedes evolution of sociality in bees.
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DOI：
10.1186/s13059-015-0628-y
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发表时间：
2015-04-24
期刊：
影响因子：
12.3
通讯作者：
Schmid-Hempel P
中科院分区：
文献类型：
--
作者：
Barribeau SM;Sadd BM;du Plessis L;Brown MJ;Buechel SD;Cappelle K;Carolan JC;Christiaens O;Colgan TJ;Erler S;Evans J;Helbing S;Karaus E;Lattorff HM;Marxer M;Meeus I;Näpflin K;Niu J;Schmid-Hempel R;Smagghe G;Waterhouse RM;Yu N;Zdobnov EM;Schmid-Hempel P
社会性有许多好处，但也可能是危险的，因为社会性昆虫中常见的高人口密度和低遗传多样性是寄生虫传播的理想选择。尽管有这种风险，蜜蜂和其他测序的社会昆虫相对于独居昆虫具有少得多的典型免疫基因。对感染的社会保障，包括行为反应，可以解释这种免疫缺陷。在这里，基于全基因组序列，我们描述了两个生态和商业上重要的大黄蜂物种，分歧约1800万年前，北美熊蜂凤仙花和欧洲熊蜂terrestris的免疫库。我们发现，这些大黄蜂的免疫系统，两种蜜蜂，和一个孤独的切叶蜂，是惊人的相似。转录测定证实了许多这些基因的表达在免疫学方面，更强烈地在年轻的皇后比男性，肯定贝特曼的原则，更大的投资在女性免疫力。我们发现的证据，积极选择的基因编码的抗病毒反应，组件的Toll和JAK/STAT途径，丝氨酸蛋白酶抑制剂在社会和孤独的蜜蜂。最后，我们检测到许多基因的途径，不同的大黄蜂和蜜蜂之间的选择，或社会和孤独的分支。免疫补体在社会性梯度上的相似性表明，蜜蜂的社会性进化之前，免疫库就已经减少了。免疫基因选择的差异可能反映了寄生虫在不同社会环境中施加的不同压力。本文的在线版本（doi：10.1186/s13059-015-0628-y）包含补充材料，可供授权用户使用。
Sociality has many rewards, but can also be dangerous, as high population density and low genetic diversity, common in social insects, is ideal for parasite transmission. Despite this risk, honeybees and other sequenced social insects have far fewer canonical immune genes relative to solitary insects. Social protection from infection, including behavioral responses, may explain this depauperate immune repertoire. Here, based on full genome sequences, we describe the immune repertoire of two ecologically and commercially important bumblebee species that diverged approximately 18 million years ago, the North American Bombus impatiens and European Bombus terrestris. We find that the immune systems of these bumblebees, two species of honeybee, and a solitary leafcutting bee, are strikingly similar. Transcriptional assays confirm the expression of many of these genes in an immunological context and more strongly in young queens than males, affirming Bateman’s principle of greater investment in female immunity. We find evidence of positive selection in genes encoding antiviral responses, components of the Toll and JAK/STAT pathways, and serine protease inhibitors in both social and solitary bees. Finally, we detect many genes across pathways that differ in selection between bumblebees and honeybees, or between the social and solitary clades. The similarity in immune complement across a gradient of sociality suggests that a reduced immune repertoire predates the evolution of sociality in bees. The differences in selection on immune genes likely reflect divergent pressures exerted by parasites across social contexts. The online version of this article (doi:10.1186/s13059-015-0628-y) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Bielawski, JP;Yang, ZH
通讯作者：
Yang, ZH
影响因子：
56.9
作者：
Garibaldi, Lucas A.;Steffan-Dewenter, Ingolf;Klein, Alexandra M.
通讯作者：
Klein, Alexandra M.
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3
作者：
Arvidsson S;Kwasniewski M;Riaño-Pachón DM;Mueller-Roeber B
通讯作者：
Mueller-Roeber B