Hemodynamic alterations in diabetic retinopathy.
Hemodynamic alterations in diabetic retinopathy.
复制标题
糖尿病视网膜病变的血流动力学改变。
DOI：
10.1016/s0161-6420(96)30514-9
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发表时间：
1996
期刊：
影响因子：
13.7
通讯作者：
B. Hasanreisoǧlu
中科院分区：
文献类型：
--
作者：
Dilek Güven;Hakan Ozdemir;B. Hasanreisoǧlu
目的：本研究旨在探讨糖尿病患者和不同阶段的retinopathy.Methods：73眼糖尿病患者的球后循环的特点和血糖控制的作用被分配到以下四个研究组之一：非增殖性糖尿病视网膜病变（非PDR），增殖性糖尿病视网膜病变（PDR），后全视网膜光凝（PRP），或preretinopathy（对照组）。应用彩色多普勒超声检测视网膜中央动脉（CRA）、视网膜中央静脉（CRV）、睫状后动脉（PCA）和眼动脉收缩期峰值血流速度。糖化血红蛋白（HbA 1c）水平被用作血糖控制的指标。结果：作者发现视网膜病变前组的CRA最大血流速度水平（9.8 ± 2.1 cm/s）显著高于非PDR组（8.1 ± 2.2 cm/s）。此外，视网膜病变前组的CRV最大血流速度水平（5.7 ± 0.9 cm/s）显著高于PDR组（4.8 ± 1.5 cm/s）和PRP组（4.9 ± 1.7 cm/s）。视网膜病变组间眼动脉和PCA的血流速度水平无显著差异。未发现HbA 1c水平与视网膜病变的分期之间存在相关性。全身性高血压的存在没有显着影响血流速度在不同的视网膜病变groups.Conclusion：本研究表明，存在一些循环变化的CRA和CRV的糖尿病视网膜病变患者的眼睛相比，患者的眼睛在视网膜病变前阶段的疾病。这些数据支持了糖尿病视网膜病变发病过程中球后循环和微循环发生变化的论点。这些发现的临床意义需要确定。
Purpose:This study was designed to examine the characteristics of retrobulbar circulation and the role of glycemic control in patients with diabetes and varying stages of retinopathy.Methods:Seventy-three eyes in 37 patients with diabetes were assigned to one of the following four study groups: nonproliferative diabetic retinopathy (non-PDR), proliferative diabetic retinopathy (PDR), post-panretinal photocoagulation (PRP), or preretinopathy (the control group). Color Doppler imaging was used to quantitate peak systolic blood flow velocities of the central retinal artery (CRA), the central retinal vein (CRV), the posterior ciliary artery (PCA) and the ophthalmic artery. Glycated hemoglobin (HbA1c) levels were used as an indicator of glycemic control.Results:The authors found that the CRA maximum blood flow velocity levels were significantly higher in the pre-retinopathy group (9.8 ± 2.1 cm/second) than in the nonPDR group (8.1 ± 2.2 cm/second). In addition, the CRV maximum blood flow velocity levels were significantly higher in the pre-retinopathy group (5.7 ± 0.9 cm/second) than in both the PDR group (4.8 ± 1.5 cm/second) and the PRP group (4.9 ± 1.7 cm/second). No significant differences were seen in blood flow velocity levels of the ophthalmic artery and the PCA among the retinopathy groups. No correlation was found between HbA1c levels and the stage of retinopathy. The presence of systemic hypertension showed no significant effect on blood flow velocities in the various retinopathy groups.Conclusion:This study demonstrates the presence of some circulatory changes in the CRA and the CRV in patients' eyes with diabetic retinopathy when compared with patients' eyes in the pre-retinopathy stage of the disease. These data support the contention that changes in retrobulbar circulation and microcirculation occur during the pathogenesis of diabetic retinopathy. The clinical significance of these findings needs to be determined.
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增殖性糖尿病视网膜病变的视网膜血流调节和全视网膜光凝的临床反应。
影响因子：
13.7
作者：
Grunwald,JE;Brucker,AJ;Petrig,BL;Riva,CE
通讯作者：
Riva,CE
影响因子：
13.7
作者：
G. Feke;H. Tagawa;A. Yoshida;D. Goger;J. Weiter;S. Buzney;J. Mcmeel
通讯作者：
G. Feke;H. Tagawa;A. Yoshida;D. Goger;J. Weiter;S. Buzney;J. Mcmeel
糖尿病患者黄斑视网膜毛细血管血流动力学。
影响因子：
13.7
作者：
Sinclair,SH
通讯作者：
Sinclair,SH
增殖性糖尿病视网膜病变的视网膜血流动力学。
影响因子：
4.4
作者：
Grunwald,JE;Brucker,AJ;Grunwald,SE;Riva,CE
通讯作者：
Riva,CE