The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancers.
The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancers.
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改变的 eIF3a 及其与 p27 在非小细胞肺癌中的关联的预后价值
DOI：
10.1371/journal.pone.0096008
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhou HH
中科院分区：
文献类型：
--
作者：
Shen J;Yin JY;Li XP;Liu ZQ;Wang Y;Chen J;Qu J;Xu XJ;McLeod HL;He YJ;Xia K;Jia YW;Zhou HH
背景非小细胞肺癌（NSCLC）中真核起始因子3a（eIF 3a）的过表达有助于增加顺铂的敏感性。然而，eIF 3a在肿瘤发生中的作用仍存在争议。本研究旨在研究eIF 3a和p27对根治性切除NSCLC患者预后的影响。方法采用免疫组织化学方法检测537例NSCLC根治术患者和210例Ⅱ期NSCLC患者中eIF 3a和p27的表达水平。采用Kaplan-Meier法和考克斯回归模型分析疾病特异性生存期（DSS）和无病生存期（DFS）。结果eIF 3 a亚细胞表达与p2 7表达状态密切相关（胞浆eIF 3 a与p2 7表达的斯皮尔曼等级相关系数为0.6 5 3，胞核表达的等级相关系数为0.716）。 此外，生存分析显示细胞核eIF 3a、p27和联合高核染色对NSCLC的预后有有利影响（风险比= 0.360，95%CI = 0.109-0.782，P = 0.028）。 此外，生物标志物和化疗状态之间的相互作用研究显示，以顺铂为基础的方案有延长具有高eIF 3a-C（P = 0.036）和低p27-N（P = 0.031）的II期NSCLC患者的DSS的趋势。 结论eIF 3a表达与p27状态密切相关，其表达与NSCLC的预后密切相关。eIF 3a和p27的表达改变可独立预测NSCLC的预后。
Background Over-expressed eukaryotic initiation factor 3a (eIF3a) in non-small cell lung cancer (NSCLC) contributed to cisplatin sensitivity. However, the role of eIF3a in oncogenesis was still controversial. This study was designed to investigate the prognostic impact of eIF3a and p27 in radically resected NSCLC patients. Methods The expression levels of subcellular eIF3a and p27 were evaluated immunohistochemically in 537 radically resected NSCLC samples, and another cohort of 210 stage II NSCLC patients. Disease specific survival (DSS) and disease free survival (DFS) were analyzed by Kaplan-Meier method and Cox regression model. Results The subcellular expression of eIF3a was strongly correlated with status of p27 (Spearman rank coefficient correlation for cytoplasmic eIF3a and p27 = 0.653, for nuclear staining = 0.716). Moreover, survival analysis revealed favorable prognostic impact of nuclear eIF3a, p27, and the combination high nuclear staining on NSCLC (Hazards Ratio = 0.360, 95%CI = 0.109–0.782, P = 0.028). In addition, interaction research between biomarkers and chemotherapy status disclosed cisplatin-based regimen trend to prolong DSS of stage II NSCLC patients with high eIF3a-C (P = 0.036)and low p27-N (P = 0.031). Conclusions Our findings suggested altered eIF3a expression closely correlated with p27 status, and the association was of prognostic value for resected NSCLC. Altered expression of eIF3a and p27 predicted prognosis of NSCLC independently.
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影响因子：
5.7
作者：
Liu RY;Dong Z;Liu J;Zhou L;Huang W;Khoo SK;Zhang Z;Petillo D;Teh BT;Qian CN;Zhang JT
通讯作者：
Zhang JT
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
eIF3a rs3740556 的 A/G 等位基因预测肺癌患者对铂类化疗的耐药性
影响因子：
5.3
作者：
Xu, Xiaojing;Han, Lifang;Liu, Zhaoqian
通讯作者：
Liu, Zhaoqian
影响因子：
4.3
作者：
Blagosklonny, Mikhail V.
通讯作者：
Blagosklonny, Mikhail V.
影响因子：
158.5
作者：
Le Chevalier, T;Arriagada, R;Wedel, H
通讯作者：
Wedel, H