Intestinal Stem Cell Development in the Neonatal Gut: Pathways Regulating Development and Relevance to Necrotizing Enterocolitis.
Intestinal Stem Cell Development in the Neonatal Gut: Pathways Regulating Development and Relevance to Necrotizing Enterocolitis.
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DOI：
10.3390/cells10020312
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发表时间：
2021-02-03
期刊：
影响因子：
6
通讯作者：
Sampath V
中科院分区：
文献类型：
--
作者：
Venkatraman A;Yu W;Nitkin C;Sampath V
肠道是非常动态的，并且内衬肠道的上皮细胞每3-5天被高度增殖的肠道干细胞（ISCs）取代。ISC自我更新或分化的指令来自其周围的微环境或其生态位。少数进化上保守的信号通路作为成体肠中干细胞的关键调节因子，并且这些通路被很好地表征。然而，机制，营养和环境信号，帮助建立干细胞生态位在新生儿肠道研究较少。破译调节干细胞发育和维持的关键信号通路对于理解肠道如何从坏死性小肠结肠炎再生特别重要，坏死性小肠结肠炎是新生儿的一种毁灭性疾病，其特征是炎症，组织坏死和干细胞损伤。在这篇综述中，我们拼凑了目前的知识形态发生和免疫途径，调节新生儿肠道干细胞，并强调这些途径之间的串扰如何影响组织再生。我们进一步讨论了这些关键途径在NEC中是如何受到干扰的，并回顾了从NEC的临床前实验模型中收集到的与NEC干细胞治疗选择相关的科学知识。
The intestine is extremely dynamic and the epithelial cells that line the intestine get replaced every 3–5 days by highly proliferative intestinal stem cells (ISCs). The instructions for ISCs to self-renew or to differentiate come as cues from their surrounding microenvironment or their niche. A small number of evolutionarily conserved signaling pathways act as a critical regulator of the stem cells in the adult intestine, and these pathways are well characterized. However, the mechanisms, nutritional, and environmental signals that help establish the stem cell niche in the neonatal intestine are less studied. Deciphering the key signaling pathways that regulate the development and maintenance of the stem cells is particularly important to understanding how the intestine regenerates from necrotizing enterocolitis, a devastating disease in newborn infants characterized by inflammation, tissues necrosis, and stem cell injury. In this review, we piece together current knowledge on morphogenetic and immune pathways that regulate intestinal stem cell in neonates and highlight how the cross talk among these pathways affect tissue regeneration. We further discuss how these key pathways are perturbed in NEC and review the scientific knowledge relating to options for stem cell therapy in NEC gleaned from pre-clinical experimental models of NEC.
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DOI：
10.1083/jcb.200311021
发表时间：
2004-07-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blache P;van de Wetering M;Duluc I;Domon C;Berta P;Freund JN;Clevers H;Jay P
通讯作者：
Jay P
影响因子：
3.6
作者：
Afrazi A;Sodhi CP;Richardson W;Neal M;Good M;Siggers R;Hackam DJ
通讯作者：
Hackam DJ
DOI：
10.1073/pnas.0401710101
发表时间：
2004-05-11
影响因子：
11.1
作者：
Claud, EC;Lu, L;Cherayil, BJ
通讯作者：
Cherayil, BJ
DOI：
10.1111/1471-0528.15799
发表时间：
2020-01-01
影响因子：
5.8
作者：
Coker, M. O.;Hoen, A. G.;Madan, J. C.
通讯作者：
Madan, J. C.
影响因子：
3.6
作者：
Cario, E;Podolsky, DK
通讯作者：
Podolsky, DK